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Household level spatio-temporal analysis of Plasmodium falciparum and Plasmodium vivax malaria in Ethiopia

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dc.contributor.author Seyoum, Dinberu
dc.contributor.author Yewhalaw, Delenasaw
dc.contributor.author Duchateau, Luc
dc.contributor.author Brandt, Patrick
dc.contributor.author Rosas-Aguirre, Angel
dc.contributor.author Speybroeck, Niko
dc.date.accessioned 2019-01-25T15:18:36Z
dc.date.available 2019-01-25T15:18:36Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4674
dc.description.abstract Background: The global decline of malaria burden and goals for elimination has led to an increased interest in the fine-scale epidemiology of malaria. Micro-geographic heterogeneity of malaria infection could have implications for designing targeted small-area interventions. Methods: Two-year longitudinal cohort study data were used to explore the spatial and spatio-temporal distribution of malaria episodes in 2040 children aged < 10 years in 16 villages near the Gilgel-Gibe hydropower dam in Southwest Ethiopia. All selected households (HHs) were geo-referenced, and children were followed up through weekly house-to-house visits for two consecutive years to identify febrile episodes of P. falciparum and P. vivax infections. After confirming the spatial dependence of malaria episodes with Ripley’s K function, SatScanTM was used to identify purely spatial and space-time clusters (hotspots) of annual malaria incidence for 2 years follow-up: year 1 (July 2008-June 2009) and year 2 (July 2009-June 2010). Results: In total, 685 P. falciparum episodes (in 492 HHs) and 385 P. vivax episodes (in 290 HHs) were identified, representing respectively incidence rates of 14.6 (95% CI: 13.4–15.6) and 8.2 (95% CI: 7.3–9.1) per 1000 child-months at risk. In year 1, the most likely (128 HHs with 63 episodes, RR = 2.1) and secondary (15 HHs with 12 episodes, RR = 5.31) clusters of P. vivax incidence were found respectively in southern and north-western villages; while in year 2, the most likely cluster was located only in north-western villages (85 HHs with 16 episodes, RR = 4.4). Instead, most likely spatial clusters of P. falciparum incidence were consistently located in villages south of the dam in both years: year 1 (167 HHs with 81 episodes, RR = 1.8) and year 2 (133 HHs with 67 episodes, RR = 2.2). Space-time clusters in southern villages for P. vivax were found in August-November 2008 in year 1 and between November 2009 and February 2010 in year 2; while for P. falciparum, they were found in September-November 2008 in year 1 and October-November 2009 in year 2. Conclusion: Hotspots of P. falciparum incidence in children were more stable at the geographical level and over time compared to those of P. vivax incidence during the study period. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1756-3305
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Longitudinal Studies en_US
dc.subject Child en_US
dc.subject Plasmodium vivax en_US
dc.subject Child, Preschool en_US
dc.subject Rural Population en_US
dc.subject Cost of Illness en_US
dc.subject Plasmodium falciparum en_US
dc.subject Incidence en_US
dc.subject Ethiopia en_US
dc.subject Family Characteristics en_US
dc.subject Spatio-Temporal Analysis en_US
dc.subject Active case detection en_US
dc.subject Disease Eradication en_US
dc.subject Ethiopia/epidemiology en_US
dc.subject Malaria, Falciparum/diagnosis/epidemiology/parasitology en_US
dc.subject Malaria, Vivax/diagnosis/epidemiology/parasitology en_US
dc.subject Plasmodium falciparum/isolation & purification en_US
dc.subject Plasmodium vivax/isolation & purification en_US
dc.subject SatScan en_US
dc.subject Spatio-temporal analysis en_US
dc.title Household level spatio-temporal analysis of Plasmodium falciparum and Plasmodium vivax malaria in Ethiopia en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s13071-017-2124-6
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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