Universidad Peruana Cayetano Heredia

Immunophenotypic Shifts in Primary Cutaneous gammadelta T-Cell Lymphoma Suggest Antigenic Modulation: A Study of Sequential Biopsy Specimens

Mostrar el registro sencillo del ítem

dc.contributor.author Agbay, Rose Lou Marie C.
dc.contributor.author Torres-Cabala, Carlos A.
dc.contributor.author Patel, Keyur P.
dc.contributor.author Merril, Eric D.
dc.contributor.author Duvic, Madeleine
dc.contributor.author Quesada, Andres
dc.contributor.author Prieto, Victor G.
dc.contributor.author Aung, Phyu P.
dc.contributor.author Loghavi, Sanam
dc.contributor.author Young, Ken H.
dc.contributor.author Hu, Shimin
dc.contributor.author Ferrufino-Schmidt, Maria C.
dc.contributor.author Tetzlaff, Michael
dc.contributor.author Li, Shaoying
dc.contributor.author Medeiros, L. Jeffrey
dc.contributor.author Miranda, Roberto N.
dc.date.accessioned 2019-01-25T15:18:37Z
dc.date.available 2019-01-25T15:18:37Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4676
dc.description.abstract Primary cutaneous gammadelta T-cell lymphoma (PCGD TCL), an aggressive type of lymphoma, accounts for approximately 1% of all primary cutaneous lymphomas. We have occasionally observed changes in T-cell antigen expression (immunophenotypic [IP] shift) over time, a phenomenon that is considered rare in T-cell lymphoma including cutaneous T-cell lymphoma. Therefore, we assessed sequential biopsies of PCGD TCL for possible IP shifts of the lymphoma cells. We searched for cases of PCGD TCL with consecutive biopsies to perform a comprehensive immunohistochemical analysis of paired specimens. A median of 12 markers per case was tested. We evaluated the percentage of neoplastic lymphocytes and determined the differential expression of antigens (gain, loss, increase or decrease). We identified 9 patients with PCGD TCL with consecutive biopsies. All (100%) cases had IP shifts of at least 1 antigen, whereas overall 22 pairs of markers were shifted: gain of reactivity occurred in 7 (31.8%) and loss in 3 (13.6%); increased reactivity in 4 (18.2%) and decreased in 8 (36.4%). Molecular analysis of TCRgamma showed identically sized monoclonal rearrangements between biopsy pairs in 4/4 (100%) patients. There was no correlation between IP shifts and the clinical appearance of lesions, histopathologic or cytologic features, or molecular rearrangements. IP shifts are common in PCGD TCL, occurring in all patients in this study and involving a variety of antigens. IP shifts do not seem to be linked to changes in the T-cell clone and are without obvious clinical or morphologic correlates. The occurrence of IP shifts in PCGD TCL suggests that antigen modulation may be involved in pathogenesis. IP shifts are somewhat frequent in T-cell lymphoma; however, it does not suggest a second neoplasm, and molecular studies can be used to determine clonal identity. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries American Journal of Surgical Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Survival Analysis en_US
dc.subject Treatment Outcome en_US
dc.subject Aged, 80 and over en_US
dc.subject Biopsy en_US
dc.subject Time Factors en_US
dc.subject Child, Preschool en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject Phenotype en_US
dc.subject Immunohistochemistry en_US
dc.subject Antigens, Neoplasm/genetics/immunology en_US
dc.subject Biomarkers, Tumor/genetics/immunology en_US
dc.subject Immunophenotyping/methods en_US
dc.subject In Situ Hybridization en_US
dc.subject Lymphoma, T-Cell, Cutaneous/genetics/immunology/pathology/therapy en_US
dc.subject Receptors, Antigen, T-Cell, gamma-delta/genetics/immunology en_US
dc.subject Skin Neoplasms/genetics/immunology/pathology/therapy en_US
dc.subject T-Lymphocytes/immunology/pathology en_US
dc.title Immunophenotypic Shifts in Primary Cutaneous gammadelta T-Cell Lymphoma Suggest Antigenic Modulation: A Study of Sequential Biopsy Specimens en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1097/PAS.0000000000000786
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.11
dc.relation.issn 1532-0979


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas