Killing of Cryptosporidium sporozoites by Lactoferrin

White, A. Clinton; Martinez-Traverso, Griselle; Ochoa Woodell, Theresa Jean; Sparks, Hayley; Paredes, Jose Luis; Castellanos-González, Alejandro

dc.contributor.author	Paredes, Jose Luis
dc.contributor.author	Sparks, Hayley
dc.contributor.author	White, A. Clinton
dc.contributor.author	Martinez-Traverso, Griselle
dc.contributor.author	Ochoa Woodell, Theresa Jean
dc.contributor.author	Castellanos-González, Alejandro
dc.date.accessioned	2019-01-25T15:28:04Z
dc.date.available	2019-01-25T15:28:04Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4685
dc.description.abstract	Intestinal infection caused by Cryptosporidium is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk. It has showed bacteriostatic and antimicrobial activity in the intestine. However, the effects of lactoferrin on the intestinal parasite Cryptosporidium have not been reported. In this study, we investigated the anticryptosporidial activity of human lactoferrin on different stages of Cryptosporidium. Physiologic concentrations of lactoferrin killed Cryptosporidium parvum sporozoites, but had no significant effect on oocysts viability or parasite intracellular development. Since sporozoites are essential for the infection process, our data reinforce the importance of breastfeeding and point to the potential of lactoferrin as a novel therapeutic agent for cryptosporidiosis.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Cryptosporidium/drug effects	en_US
dc.subject	Humans	en_US
dc.subject	Lactoferrin/chemistry/pharmacology	en_US
dc.subject	Milk, Human/chemistry	en_US
dc.subject	Oocysts/drug effects	en_US
dc.subject	Sporozoites/drug effects	en_US
dc.title	Killing of Cryptosporidium sporozoites by Lactoferrin	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.16-0804
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645