Universidad Peruana Cayetano Heredia

Laboratory Evaluation of a Smartphone-Based Electronic Reader of Rapid Dual Point-of-Care Tests for Antibodies to Human Immunodeficiency Virus and Treponema pallidum Infections

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dc.contributor.author Herbst de Cortina, Sasha
dc.contributor.author Bristow, Claire C.
dc.contributor.author Humphries, Romney
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Konda, Kelika A.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, Jeffrey D.
dc.date.accessioned 2019-01-25T15:28:04Z
dc.date.available 2019-01-25T15:28:04Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4688
dc.description.abstract BACKGROUND: Dual point-of-care tests for antibodies to human immunodeficiency virus (HIV) and Treponema pallidum allow for same-day testing and treatment and have been demonstrated to be cost-effective in preventing the adverse outcomes of HIV infection and syphilis. By recording and transmitting data as they are collected, electronic readers address challenges related to the decentralization of point-of-care testing. METHODS: We evaluated a smartphone-based electronic reader using 201 sera tested with 2 dual rapid tests for detection of antibodies to HIV and T. pallidum in Los Angeles, USA, and Lima, Peru. Tests were read both visually and with the electronic reader. Enzyme immunoassay followed by Western blot and T. pallidum particle agglutination were the reference tests for HIV and T. pallidum, respectively. RESULTS: The sensitivities of the 2 rapid tests for detection of HIV were 94.1% and 97.0% for electronic readings. Both tests had a specificity of 100% for detection of HIV by electronic reading. The sensitivities of the 2 rapid tests for detection of T. pallidum were 86.5% and 92.4% for electronic readings. The specificities for detection of T. pallidum were 99.1% and 99.0% by electronic reading. There were no significant differences between the accuracies of visual and electronic readings, and the performance did not differ between the 2 study sites. CONCLUSIONS: Our results show the electronic reader to be a promising option for increasing the use of point-of-care testing programs. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Sexually Transmitted Infections
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Sensitivity and Specificity en_US
dc.subject Reproducibility of Results en_US
dc.subject Peru/epidemiology en_US
dc.subject Point-of-Care Systems/economics/standards en_US
dc.subject Smartphone/instrumentation en_US
dc.subject HIV Antibodies/analysis/immunology en_US
dc.subject HIV Infections/diagnosis/economics/immunology/virology en_US
dc.subject Immunoenzyme Techniques/economics/instrumentation/standards en_US
dc.subject Los Angeles/epidemiology en_US
dc.subject Syphilis/diagnosis/economics/immunology/microbiology en_US
dc.subject Treponema pallidum/immunology en_US
dc.title Laboratory Evaluation of a Smartphone-Based Electronic Reader of Rapid Dual Point-of-Care Tests for Antibodies to Human Immunodeficiency Virus and Treponema pallidum Infections en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1097/OLQ.0000000000000628
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn 1472-3263


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