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Lactoferrin concentration in breast milk of mothers of low-birth-weight newborns

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dc.contributor.author Turin, C. G.
dc.contributor.author Zea-Vera, A.
dc.contributor.author Rueda, M. S.
dc.contributor.author Mercado, E.
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Zegarra, J.
dc.contributor.author Bellomo, S.
dc.contributor.author Cam, L.
dc.contributor.author Castaneda, A.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2019-01-25T15:28:04Z
dc.date.available 2019-01-25T15:28:04Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4689
dc.description.abstract OBJECTIVES: Lactoferrin (LF) is a breast milk glycoprotein with protective effects against neonatal infections, mainly in premature and low-birth-weight (LBW) neonates. The aims of this study were to determine LF concentration in breast milk of mothers of LBW infants during the first 2 months postpartum, and to identify the factors associated with LF concentration. STUDY DESIGN: Prospective study conducted as a part of an ongoing clinical trial in three Neonatal Units in Peru. We included 346 mothers of neonates with a birth weight <2000 g. We measured LF concentration in four stages of lactation using a commercial enzyme-linked immunosorbent assay kit. Multivariate analysis was performed to assess the association between maternal and neonatal factors, and LF concentration. RESULTS: We collected 695 milk samples. LF mean concentration+/-standard deviation was 14.92+/-7.96 mg ml(-1) in colostrum (n=277), 10.73+/-5.67 in transitional milk (n=55), 10.34+/-6.27 at 1 month (n=259) and 8.52+/-6.47 at 2 months (n=104). There was a significant difference in LF concentration between different stages of lactation (P<0.001). Mothers with higher LF concentration in colostrum had higher values in the following 2 months. High maternal income and multiple gestation were significantly associated with higher LF levels; in contrast, maternal peripartum infections and male neonatal gender were associated with lower LF levels. CONCLUSIONS: LF concentration in breast milk of mothers of LBW infants was high and remained elevated even at 1 and 2 months postpartum. LF concentration in colostrum was higher in mothers with higher income and multiple pregnancies, and lower in mothers with peripartum infections. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Journal of Perinatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Pregnancy en_US
dc.subject Multivariate Analysis en_US
dc.subject Prospective Studies en_US
dc.subject Income en_US
dc.subject Infant en_US
dc.subject Infant, Newborn en_US
dc.subject Linear Models en_US
dc.subject Breast Feeding en_US
dc.subject Postpartum Period en_US
dc.subject Pregnancy, Multiple en_US
dc.subject Infant, Low Birth Weight en_US
dc.subject Premature Birth en_US
dc.subject Colostrum/chemistry en_US
dc.subject Lactation/physiology en_US
dc.subject Lactoferrin/analysis en_US
dc.subject Milk, Human/chemistry en_US
dc.title Lactoferrin concentration in breast milk of mothers of low-birth-weight newborns en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/jp.2016.265
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.relation.issn 1476-5543


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