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Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults

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dc.contributor.author Lüneburg, Nicole
dc.contributor.author Siques, Patricia
dc.contributor.author Brito, Julio
dc.contributor.author De La Cruz, Juan Jose
dc.contributor.author Leon-Velarde, Fabiola
dc.contributor.author Hannemann, Juliane
dc.contributor.author Ibanez, Cristian
dc.contributor.author Boger, Rainer H.
dc.date.accessioned 2019-01-25T15:28:05Z
dc.date.available 2019-01-25T15:28:05Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4693
dc.description.abstract Hypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway. We measured asymmetric and symmetric dimethylarginine (ADMA and SDMA) and monomethyl-L-arginine (L-NMMA) and assessed their associations with acclimatization in male draftees (n = 72) undergoing CIH shifts at altitude (3550 m) during 3 months. Sixteen Andean natives living at altitude (3675 m) (chronic hypobaric hypoxia [CH]) were included for comparison. In CIH, ADMA and L-NMMA plasma concentrations increased from 1.14 +/- 0.04 to 1.95 +/- 0.09 mumol/L (mean +/- SE) and from 0.22 +/- 0.07 to 0.39 +/- 0.03 mumol/L, respectively, (p < 0.001 for both) after 3 months, whereas SDMA did not change. The concentrations of ADMA and L-NMMA were higher in CH (3.48 +/- 0.07, 0.53 +/- 0.08 mumol/L; p < 0.001) as compared with CIH. In both CIH and CH, ADMA correlated with hematocrit (r(2) = 0.07, p < 0.05; r(2) = 0.26; p < 0.01). In CIH, an association of ADMA levels with poor acclimatization status was observed. We conclude that the endogenous NO synthase inhibitors, ADMA and L-NMMA, are elevated in hypoxia. This may contribute to impaired NO production at altitude and may also be predictive of altitude-associated health impairment. en_US
dc.language.iso eng
dc.publisher Mary Ann Liebert
dc.relation.ispartof urn:issn:1557-8682
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject high altitude en_US
dc.subject Chile en_US
dc.subject acclimatization en_US
dc.subject Altitude en_US
dc.subject Acclimatization/physiology en_US
dc.subject acute mountain sickness en_US
dc.subject ADMA en_US
dc.subject Altitude Sickness/etiology en_US
dc.subject Arginine/analogs & derivatives/blood en_US
dc.subject Hypoxia/blood en_US
dc.subject intermittent hypoxia en_US
dc.subject Military Personnel en_US
dc.subject Occupational Diseases/etiology en_US
dc.subject omega-N-Methylarginine/blood en_US
dc.title Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1089/ham.2016.0123
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.11
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05

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