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Maternal and pregnancy-related factors affecting human milk cytokines among Peruvian mothers bearing low-birth-weight neonates

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dc.contributor.author Zambruni, Mara
dc.contributor.author Villalobos, Alex
dc.contributor.author Somasunderam, Anoma
dc.contributor.author Westergaard, Sarah
dc.contributor.author Nigalye, Maitreyee
dc.contributor.author Turin, Christie G.
dc.contributor.author Zegarra, Jaime
dc.contributor.author Bellomo, Sicilia
dc.contributor.author Mercado, Erik
dc.contributor.author Ochoa, Theresa J.
dc.contributor.author Utay, Netanya S.
dc.date.accessioned 2019-01-25T15:28:05Z
dc.date.available 2019-01-25T15:28:05Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4698
dc.description.abstract Several cytokines have been detected in human milk but their relative concentrations differ among women and vary over time in the same person. The drivers of such differences have been only partially identified, while the effect of luminal cytokines in the fine-regulation of the intestinal immune system is increasingly appreciated. The aim of this study was to investigate the associations between obstetrical complications and human milk cytokine profiles in a cohort of Peruvian women giving birth to Low Birth Weight (LBW) infants. Colostrum and mature human milk samples were collected from 301 Peruvian women bearing LBW infants. The concentration of twenty-three cytokines was measured using the Luminex platform. Ninety-nine percent of women had at least one identified obstetrical complication leading to intra-uterine growth restriction and/or preterm birth. Median weight at birth was 1,420g; median gestational age 31 weeks. A core of 12 cytokines, mainly involved in innate immunity and epithelial cell integrity, was detectable in most samples. Maternal age, maternal infection, hypertensive disorders, preterm labor, and premature rupture of membranes were associated with specific cytokine profiles both in colostrum and mature human milk. Mothers of Very LBW (VLBW) neonates had significantly higher concentrations of chemokines and growth factor cytokines both in their colostrum and mature milk compared with mothers of larger neonates. Thus, maternal conditions affecting pregnancy duration and in utero growth are also associated with specific human milk cytokine signatures. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1872-7603
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Young Adult en_US
dc.subject Pregnancy en_US
dc.subject Risk Factors en_US
dc.subject Cohort Studies en_US
dc.subject Infant, Newborn en_US
dc.subject Transcriptome en_US
dc.subject Human milk cytokines en_US
dc.subject Infant, Low Birth Weight en_US
dc.subject Low-birth weight infants en_US
dc.subject Pregnancy complications en_US
dc.subject Cytokines/metabolism en_US
dc.subject Immunity, Innate en_US
dc.subject Lactation/immunology en_US
dc.subject Maternal Age en_US
dc.subject Milk, Human/metabolism en_US
dc.subject Pregnancy Complications, Cardiovascular/epidemiology/immunology en_US
dc.subject Premature Birth/epidemiology/immunology en_US
dc.title Maternal and pregnancy-related factors affecting human milk cytokines among Peruvian mothers bearing low-birth-weight neonates en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jri.2017.04.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.08

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