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dc.contributor.author | Montenegro-Garreaud, Ximena | |
dc.contributor.author | Miranda, Roberto N. | |
dc.contributor.author | Reynolds, Alexandra | |
dc.contributor.author | Tang, Guilin | |
dc.contributor.author | Wang, Sa A. | |
dc.contributor.author | Yabe, Mariko | |
dc.contributor.author | Wang, Wei | |
dc.contributor.author | Fang, Lianghua | |
dc.contributor.author | Bueso-Ramos, Carlos E. | |
dc.contributor.author | Lin, Pei | |
dc.contributor.author | Medeiros, L. Jeffrey | |
dc.contributor.author | Lu, Xinyan | |
dc.date.accessioned | 2019-01-25T15:28:06Z | |
dc.date.available | 2019-01-25T15:28:06Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/4709 | |
dc.description.abstract | Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to lymphoblastic leukemia/lymphoma or acute myeloid leukemia. The most common partner of FGFR1 is ZMYM2, and patients with the ZMYM2-FGFR1 fusion often present with MPN and T-lymphoblastic lymphoma. There are 14 other partners that can fuse with FGFR1, and of interest is the BCR-FGFR1 fusion that results from t(8;22)(p11.2;q11.2). Patients with t(8;22) often show leukocytosis and present with an MPN resembling chronic myeloid leukemia or very rarely, with B-lymphoblastic leukemia (B-ALL). In this study, we analyzed the clinicopathological, cytogenetic, and molecular features of 2 new patients with the t(8;22)(p11.2;q11.2)/BCR-FGFR1 who presented with B-ALL. An underlying MPN became apparent when a morphologic remission of B-ALL was achieved after chemotherapy. We subsequently reviewed the literature and identified 18 additional cases reported with B-ALL in a background MPN or with the MPN as a chronic phase. Our data suggest that the t(8;22)(p11.2;q11.2)/BCR-FGFR1 may arise from a myeloid/B progenitor cell. It is important to recognize that neoplasms carrying the t(8;22)/BCR-FGFR1, although rare, can commonly with B lymphoblastic leukemia at the initial diagnosis, which could distract one from recognizing a possible underlying 8p11 myeloproliferative syndrome. | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Human Pathology | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Adolescent | en_US |
dc.subject | Adult | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Young Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Diagnosis, Differential | en_US |
dc.subject | Treatment Outcome | en_US |
dc.subject | Child | en_US |
dc.subject | Disease Progression | en_US |
dc.subject | Predictive Value of Tests | en_US |
dc.subject | Genetic Predisposition to Disease | en_US |
dc.subject | B lineage | en_US |
dc.subject | B lymphoblastic leukemia | en_US |
dc.subject | BCR | en_US |
dc.subject | Chromosomes, Human, Pair 22 | en_US |
dc.subject | Chromosomes, Human, Pair 8 | en_US |
dc.subject | Cytogenetic Analysis | en_US |
dc.subject | Cytogenetics | en_US |
dc.subject | FGFR1 rearrangement | en_US |
dc.subject | FISH | en_US |
dc.subject | Monocytosis | en_US |
dc.subject | Translocation, Genetic | en_US |
dc.subject | Antineoplastic Agents/therapeutic use | en_US |
dc.subject | Biomarkers, Tumor/genetics | en_US |
dc.subject | Databases, Factual | en_US |
dc.subject | Diagnostic Errors | en_US |
dc.subject | Gene Fusion | en_US |
dc.subject | In Situ Hybridization, Fluorescence | en_US |
dc.subject | Karyotyping | en_US |
dc.subject | Myeloproliferative Disorders/drug therapy/genetics/pathology | en_US |
dc.subject | Phenotype | en_US |
dc.subject | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/genetics/pathology | en_US |
dc.subject | Precursor Cells, B-Lymphoid/drug effects/pathology | en_US |
dc.subject | Proto-Oncogene Proteins c-bcr/genetics | en_US |
dc.subject | Receptor, Fibroblast Growth Factor, Type 1/genetics | en_US |
dc.title | Myeloproliferative neoplasms with t(8;22)(p11.2;q11.2)/BCR-FGFR1: a meta-analysis of 20 cases shows cytogenetic progression with B-lymphoid blast phase | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.humpath.2017.05.008 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.09 | |
dc.relation.issn | 1532-8392 |
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