Universidad Peruana Cayetano Heredia

N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia

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dc.contributor.author Fano Sizgorich, Diego Alejandro
dc.contributor.author Vásquez-Velásquez, Cinthya
dc.contributor.author Gonzales-Castañeda, Cynthia
dc.contributor.author Guajardo-Correa, Emanuel
dc.contributor.author Orihuela, Pedro A.
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2019-01-25T15:28:06Z
dc.date.available 2019-01-25T15:28:06Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4710
dc.description.abstract Benign Prostatic Hyperplasia (BPH) affects, worldwide, 50% of 60-year-old men. The Peruvian plant red maca (Lepidium meyenii) inhibits BPH in rodents. This study aimed to determine the effects of methanolic red maca extract and its n-butanol and aqueous fractions on expression of androgen and oestrogen receptors in rats with testosterone enanthate-induced BPH. Thirty-six rats in six groups were studied. Control group received 2 mL of vehicle orally and 0.1 mL of propylene glycol intramuscularly. The second group received vehicle orally and testosterone enanthate (TE) (25 mg/0.1 mL) intramuscularly in days 1 and 7. The other four groups were BPH-induced with TE and received, during 21 days, 3.78 mg/mL of finasteride, 18.3 mg/mL methanol extract of red maca, 2 mg/mL of n-butanol fraction, or 16.3 mg/mL of aqueous fraction from red maca. Treatments with red maca extract and its n-butanol but not aqueous fraction reduced prostate weight similar to finasteride. All maca treated groups restored the expression of ERβ, but only the aqueous fraction increased androgen receptors and ERα. In conclusion, butanol fraction of red maca reduced prostate size in BPH by restoring expression of ERβ without affecting androgen receptors and ERα. This effect was not observed with aqueous fraction of methanolic extract of red maca. en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartofseries Evidence-based Complementary and Alternative Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Red Maca en_US
dc.subject Lepidium meyenii en_US
dc.subject androgen en_US
dc.subject oestrogens en_US
dc.subject Benign Prostatic Hyperplasia en_US
dc.title N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2017/9124240
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.29
dc.relation.issn 1741-4288


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