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Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL)

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dc.contributor.author Haye Salinas, M. J.
dc.contributor.author Caeiro, F.
dc.contributor.author Saurit, V.
dc.contributor.author Alvarellos, A.
dc.contributor.author Wojdyla, D.
dc.contributor.author Scherbarth, H. R.
dc.contributor.author de O E Silva, A. C.
dc.contributor.author Tavares Brenol, J. C.
dc.contributor.author Lavras Costallat, L. T.
dc.contributor.author Neira, O. J.
dc.contributor.author Iglesias Gamarra, A.
dc.contributor.author Vasquez, G.
dc.contributor.author Reyes Llerena, G. A.
dc.contributor.author Barile-Fabris, L. A.
dc.contributor.author Silveira, L. H.
dc.contributor.author Sauza Del Pozo, M. J.
dc.contributor.author Acevedo Vasquez, E. M.
dc.contributor.author Alfaro Lozano, J. L.
dc.contributor.author Esteva Spinetti, M. H.
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Pons-Estel, B. A.
dc.date.accessioned 2019-01-25T15:28:07Z
dc.date.available 2019-01-25T15:28:07Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4723
dc.description.abstract Objectives: The objectives of this study were to examine the demographic and clinical features associated with the occurrence of pleuropulmonary manifestations, the predictive factors of their occurrence and their impact on mortality in systemic lupus erythematosus (SLE) patients. Materials and methods The association of pleuropulmonary manifestations with demographic and clinical features, the predictive factors of their occurrence and their impact on mortality were examined in GLADEL patients by appropriate univariable and multivariable analyses. Results At least one pleuropulmonary manifestation occurred in 421 of the 1480 SLE patients (28.4%), pleurisy being the most frequent (24.0%). Age at SLE onset >/=30 years (OR 1.42; 95% CI 1.10-1.83), the presence of lower respiratory tract infection (OR 3.19; 95% CI 2.05-4.96), non-ischemic heart disease (OR 3.17; 95% CI 2.41-4.18), ischemic heart disease (OR 3.39; 95% CI 2.08-5.54), systemic (OR 2.00; 95% CI 1.37-2.91), ocular (OR 1.58; 95% CI 1.16-2.14) and renal manifestations (OR 1.44; 95% CI 1.09-1.83) were associated with pleuropulmonary manifestations, whereas cutaneous manifestations were negatively associated (OR 0.47; 95% CI 0.29-0.76). Non-ischemic heart disease (HR 2.24; 95% CI 1.63-3.09), SDI scores >/=1 (OR 1.54; 95% CI 1.10-2.17) and anti-La antibody positivity (OR 2.51; 95% CI 1.39-4.57) independently predicted their subsequent occurrence. Cutaneous manifestations were protective of the subsequent occurrence of pleuropulmonary manifestations (HR 0.62; 95% CI 0.43-0.90). Pleuropulmonary manifestations independently contributed a decreased survival (HR: 2.79 95% CI 1.80-4.31). Conclusion Pleuropulmonary manifestations are frequent in SLE, particularly pleuritis. Older age, respiratory tract infection, cardiac, systemic and renal involvement were associated with them, whereas cutaneous manifestations were negatively associated. Cardiac compromise, SDI scores >/=1 and anti-La positivity at disease onset were predictive of their subsequent occurrence, whereas cutaneous manifestations were protective. They independently contributed to a decreased survival in these patients. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Cohort Studies en_US
dc.subject Epidemiology en_US
dc.subject Severity of Illness Index en_US
dc.subject Lung Diseases/etiology en_US
dc.subject Lupus Erythematosus, Systemic/complications/mortality en_US
dc.subject Pleurisy/etiology en_US
dc.subject pulmonary systemic lupus erythematosus en_US
dc.subject Respiratory Tract Infections/etiology en_US
dc.title Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL) en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/0961203317699284
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1477-0962


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