Universidad Peruana Cayetano Heredia

Porcine Cysticercosis: Possible Cross-Reactivity of Taenia hydatigena to GP50 Antigen in the Enzyme-Linked Immunoelectrotransfer Blot Assay

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dc.contributor.author Muro Ecca, Claudio Alberto
dc.contributor.author Gomez-Puerta, Luis A.
dc.contributor.author Flecker, Robert H.
dc.contributor.author Gamboa Morán, Ricardo
dc.contributor.author Barreto, Percy Vilchez
dc.contributor.author Dorny, Pierre
dc.contributor.author Tsang, Victor C. W.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author O'Neal, Seth E.
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2019-01-25T15:28:08Z
dc.date.available 2019-01-25T15:28:08Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4726
dc.description.abstract The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions. We investigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6-8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigena metacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 cross-reactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Antibodies, Helminth/blood en_US
dc.subject Antigens, Helminth/blood en_US
dc.subject Biomarkers/blood en_US
dc.subject Cross Reactions en_US
dc.subject Cysticercosis/blood/diagnosis/veterinary en_US
dc.subject Dogs/parasitology en_US
dc.subject Host-Parasite Interactions en_US
dc.subject Nerve Tissue Proteins/blood en_US
dc.subject Peru en_US
dc.subject Sensitivity and Specificity en_US
dc.subject Swine Diseases/blood/diagnosis/parasitology en_US
dc.subject Swine/parasitology en_US
dc.subject Taenia/classification/isolation & purification en_US
dc.title Porcine Cysticercosis: Possible Cross-Reactivity of Taenia hydatigena to GP50 Antigen in the Enzyme-Linked Immunoelectrotransfer Blot Assay en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.17-0378
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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