Porcine Cysticercosis: Possible Cross-Reactivity of Taenia hydatigena to GP50 Antigen in the Enzyme-Linked Immunoelectrotransfer Blot Assay

Gomez-Puerta, Luis A.; Flecker, Robert H.; García Lescano, Héctor Hugo; O'Neal, Seth E.; Tsang, Victor C. W.; Barreto, Percy Vilchez; Gilman, Robert Hugh; Cysticercosis Working Group in Peru; Muro Ecca, Claudio Alberto; Gamboa Morán, Ricardo; Dorny, Pierre; Gonzalez Zariquiey, Armando Emiliano

dc.contributor.author	Muro Ecca, Claudio Alberto
dc.contributor.author	Gomez-Puerta, Luis A.
dc.contributor.author	Flecker, Robert H.
dc.contributor.author	Gamboa Morán, Ricardo
dc.contributor.author	Barreto, Percy Vilchez
dc.contributor.author	Dorny, Pierre
dc.contributor.author	Tsang, Victor C. W.
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	O'Neal, Seth E.
dc.contributor.author	Cysticercosis Working Group in Peru
dc.date.accessioned	2019-01-25T15:28:08Z
dc.date.available	2019-01-25T15:28:08Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4726
dc.description.abstract	The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions. We investigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6-8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigena metacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 cross-reactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Animals	en_US
dc.subject	Antibodies, Helminth/blood	en_US
dc.subject	Antigens, Helminth/blood	en_US
dc.subject	Biomarkers/blood	en_US
dc.subject	Cross Reactions	en_US
dc.subject	Cysticercosis/blood/diagnosis/veterinary	en_US
dc.subject	Dogs/parasitology	en_US
dc.subject	Host-Parasite Interactions	en_US
dc.subject	Nerve Tissue Proteins/blood	en_US
dc.subject	Peru	en_US
dc.subject	Sensitivity and Specificity	en_US
dc.subject	Swine Diseases/blood/diagnosis/parasitology	en_US
dc.subject	Swine/parasitology	en_US
dc.subject	Taenia/classification/isolation & purification	en_US
dc.title	Porcine Cysticercosis: Possible Cross-Reactivity of Taenia hydatigena to GP50 Antigen in the Enzyme-Linked Immunoelectrotransfer Blot Assay	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.17-0378
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645