Universidad Peruana Cayetano Heredia

Prevalence and risk factors of restrictive spirometry in a cohort of Peruvian adults

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dc.contributor.author Siddharthan, T.
dc.contributor.author Grigsby, M.
dc.contributor.author Miele, C. H.
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Wise, R. A.
dc.contributor.author Porter, J. C.
dc.contributor.author Hurst, J. R.
dc.contributor.author Checkley, W.
dc.date.accessioned 2019-01-25T15:28:08Z
dc.date.available 2019-01-25T15:28:08Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4730
dc.description.abstract INTRODUCTION: Few studies have described the prevalence of and lung function decline among those with a restrictive spirometric pattern (RSP) in low- and middle-income countries. METHODS: We analyzed prospective data from 3055 adults recruited across four diverse settings in Peru over a 3-year period. Multivariable logistic regression was used to study the association between the presence of restriction and associated risk factors. Multivariable linear mixed models were used to determine lung function decline. RESULTS: Among 3055 participants, the average age was 55.4 years (SD 12.4); 49% were male. Overall prevalence of RSP was 4.7%, ranging from 2.8% (Lima) to 6.9% (Tumbes). The odds of having RSP were higher among those who lived in a rural environment (OR 2.19, 95%CI 1.43-3.37), had a diagnosis of diabetes (OR 1.94, 95%CI 1.10-3.40) and among women (OR 2.09, 95%CI 1.41-3.09). When adjusting for baseline lung function, adults with RSP had accelerated decline in forced expiratory volume in 1 s (FEV1) compared with non-obstructed, non-restricted individuals. DISCUSSION: RSP is prevalent particularly among women and in individuals living in rural settings of Peru. When adjusted for baseline lung function, participants with RSP had accelerated rates of FEV1 decline. Our findings are consistent with the notion that RSP is an insidious inflammatory condition with deleterious effects of lung function decline. en_US
dc.language.iso eng
dc.publisher International Union Against Tuberculosis and Lung Disease
dc.relation.ispartofseries International Journal of Tuberculosis and Lung Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Spirometry en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Altitude en_US
dc.subject Body Mass Index en_US
dc.subject C-Reactive Protein/metabolism en_US
dc.subject Female en_US
dc.subject Follow-Up Studies en_US
dc.subject Forced Expiratory Volume en_US
dc.subject Humans en_US
dc.subject Logistic Models en_US
dc.subject Longitudinal Studies en_US
dc.subject Lung Diseases, Obstructive/diagnosis/epidemiology en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Prospective Studies en_US
dc.subject Respiratory Function Tests en_US
dc.subject Risk Factors en_US
dc.subject Rural Population en_US
dc.subject Urban Population en_US
dc.subject Urbanization en_US
dc.title Prevalence and risk factors of restrictive spirometry in a cohort of Peruvian adults en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5588/ijtld.17.0101
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1815-7920


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