DSpace Repository

Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole

Show simple item record

dc.contributor.author Cangalaya, Carla
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Calcina, Juan
dc.contributor.author Vargas-Calla, Ana
dc.contributor.author Mamani, Javier
dc.contributor.author Suarez, Diego
dc.contributor.author Arroyo Hurtado, Gianfranco
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Chacaltana, Juan
dc.contributor.author Guerra-Giraldez, Cristina
dc.contributor.author Mahanty, Siddhartha
dc.contributor.author Nash, Theodore E.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-01-25T16:03:19Z
dc.date.available 2019-01-25T16:03:19Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4741
dc.description.abstract Background: The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be detected by medical imaging. We evaluated radiological changes in the appearance of brain cysts (enhancement and size) on days two and five after the onset of antiparasitic treatment using naturally infected pigs as a model for human NCC. Methods and results: Contrast T1-weighted magnetic resonance imaging with gadolinium was performed before and after antiparasitic treatment. Eight NCC-infected pigs were treated with praziquantel plus albendazole and euthanized two (n = 4) and five (n = 4) days after treatment; another group of four infected pigs served as untreated controls. For each lesion, gadolinium enhancement intensity (GEI) and cyst volume were measured at baseline and after antiparasitic treatment. Volume and GEI quantification ratios (post/pre-treatment measures) were used to appraise the effect of treatment. Cysts from untreated pigs showed little variations between their basal and post treatment measures. At days 2 and 5 there were significant increases in GEI ratio compared with the untreated group (1.32 and 1.47 vs 1.01, p = 0.021 and p = 0.021). Cyst volume ratios were significantly lower at days 2 and 5 compared with the untreated group (0.60 and 0.22 vs 0.95, p = 0.04 and p = 0.02). Cysts with lower cyst volume ratios showed more marked post-treatment inflammation, loss of vesicular fluid and cyst wall wrinkling. Conclusion/Significance: A significant and drastic reduction of cyst size and increased pericystic enhancement occur in the initial days after antiparasitic treatment as an effect of acute perilesional immune response. These significant changes showed that early anthelmintic efficacy (day two) can be detected using magnetic resonance imaging. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Male en_US
dc.subject Animals en_US
dc.subject Drug Therapy, Combination en_US
dc.subject Disease Models, Animal en_US
dc.subject Magnetic Resonance Imaging en_US
dc.subject Albendazole/administration & dosage en_US
dc.subject Anthelmintics/administration & dosage en_US
dc.subject Brain/parasitology/pathology en_US
dc.subject Cysts/diagnostic imaging/pathology en_US
dc.subject Neurocysticercosis/diagnostic imaging/drug therapy/veterinary en_US
dc.subject Praziquantel/administration & dosage en_US
dc.subject Radiography en_US
dc.subject Random Allocation en_US
dc.subject Swine Diseases/diagnostic imaging/drug therapy/parasitology en_US
dc.subject Swine/parasitology en_US
dc.title Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0005624
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics