Universidad Peruana Cayetano Heredia

Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity

Mostrar el registro sencillo del ítem

dc.contributor.author Thiersch, M.
dc.contributor.author Swenson, E. R.
dc.contributor.author Haider, T.
dc.contributor.author Gassmann, M.
dc.date.accessioned 2019-01-25T16:03:19Z
dc.date.available 2019-01-25T16:03:19Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4744
dc.description.abstract Residency at high altitude (HA) demands adaptation to challenging environmental conditions with hypobaric hypoxia being the most important one. Epidemiological and experimental data suggest that chronic exposure to HA reduces cancer mortality and lowers prevalence of metabolic disorders like diabetes and obesity implying that adaption to HA modifies a broad spectrum of physiological, metabolic and cellular programs with a generally beneficial outcome for humans. However, the complexity of multiple, potentially tumor-suppressive pathways at HA impedes the understanding of mechanisms leading to reduced cancer mortality. Many adaptive processes at HA are tightly interconnected and thus it cannot be ruled out that the entirety or at least some of the HA-related alterations act in concert to reduce cancer mortality. In this review we discuss tumor formation as a concept of competition between healthy and cancer cells with improved fitness - and therefore higher competitiveness - of healthy cells at high altitude. We discuss HA-related changes in glucose, lipid and iron metabolism that may have an impact on tumorigenesis. Additionally, we discuss two parameters with a strong impact on tumorigenesis, namely drug metabolism and physical activity, to underpin their potential contribution to HA-dependent reduced cancer mortality. Future studies are needed to unravel why cancer mortality is reduced at HA and how this knowledge might be used to prevent and to treat cancer patients. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Experimental Cell Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject Cancer mortality en_US
dc.subject Environment en_US
dc.subject Exercise en_US
dc.subject High altitude en_US
dc.subject Hypoxia en_US
dc.subject Iron en_US
dc.subject Lipids en_US
dc.subject Metabolism en_US
dc.subject Exercise/physiology en_US
dc.subject Glucose/metabolism en_US
dc.subject Hypoxia/metabolism en_US
dc.subject Iron/metabolism en_US
dc.title Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.yexcr.2017.03.048
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1090-2422


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas