Universidad Peruana Cayetano Heredia

Risk Factors for Mortality among Adult HIV/AIDS Patients Following Antiretroviral Therapy in Southwestern Ethiopia: An Assessment through Survival Models

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dc.contributor.author Seyoum, Dinberu
dc.contributor.author Degryse, Jean-Marie
dc.contributor.author Kifle, Yehenew Getachew
dc.contributor.author Taye, Ayele
dc.contributor.author Tadesse, Mulualem
dc.contributor.author Birlie, Belay
dc.contributor.author Banbeta, Akalu
dc.contributor.author Rosas-Aguirre, Angel
dc.contributor.author Duchateau, Luc
dc.contributor.author Speybroeck, Niko
dc.date.accessioned 2019-01-25T16:03:19Z
dc.date.available 2019-01-25T16:03:19Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4747
dc.description.abstract Introduction: Efforts have been made to reduce HIV/AIDS-related mortality by delivering antiretroviral therapy (ART) treatment. However, HIV patients in resource-poor settings are still dying, even if they are on ART treatment. This study aimed to explore the factors associated with HIV/AIDS-related mortality in Southwestern Ethiopia. Method: A non-concurrent retrospective cohort study which collected data from the clinical records of adult HIV/AIDS patients, who initiated ART treatment and were followed between January 2006 and December 2010, was conducted, to explore the factors associated with HIV/AIDS-related mortality at Jimma University Specialized Hospital (JUSH). Survival times (i.e., the time from the onset of ART treatment to the death or censoring) and different characteristics of patients were retrospectively examined. A best-fit model was chosen for the survival data, after the comparison between native semi-parametric Cox regression and parametric survival models (i.e., exponential, Weibull, and log-logistic). Result: A total of 456 HIV patients were included in the study, mostly females (312, 68.4%), with a median age of 30 years (inter-quartile range (IQR): 23-37 years). Estimated follow-up until December 2010 accounted for 1245 person-years at risk (PYAR) and resulted in 66 (14.5%) deaths and 390 censored individuals, representing a median survival time of 34.0 months ( IQR: 22.8-42.0 months). The overall mortality rate was 5.3/100 PYAR: 6.5/100 PYAR for males and 4.8/100 PYAR for females. The Weibull survival model was the best model for fitting the data (lowest AIC). The main factors associated with mortality were: baseline age (>35 years old, AHR = 3.8, 95% CI: 1.6-9.1), baseline weight (AHR = 0.93, 95% CI: 0.90-0.97), baseline WHO stage IV (AHR = 6.2, 95% CI: 2.2-14.2), and low adherence to ART treatment (AHR = 4.2, 95% CI: 2.5-7.1). Conclusion: An effective reduction in HIV/AIDS mortality could be achieved through timely ART treatment onset and maintaining high levels of treatment adherence. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries International Journal of Environmental Research and Public Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Retrospective Studies en_US
dc.subject Young Adult en_US
dc.subject Survival Analysis en_US
dc.subject Risk Factors en_US
dc.subject Anti-HIV Agents/therapeutic use en_US
dc.subject Ethiopia/epidemiology en_US
dc.subject antiretroviral therapy (ART) en_US
dc.subject Ethiopia en_US
dc.subject HIV/AIDS en_US
dc.subject parametric survival model en_US
dc.subject HIV Infections/drug therapy/mortality en_US
dc.subject Hospitals, University en_US
dc.title Risk Factors for Mortality among Adult HIV/AIDS Patients Following Antiretroviral Therapy in Southwestern Ethiopia: An Assessment through Survival Models en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/ijerph14030296
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.05.08
dc.relation.issn 1660-4601


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