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Spatial relationship between Taenia solium tapeworm carriers and necropsy cyst burden in pigs

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dc.contributor.author Pray, Ian W.
dc.contributor.author Ayvar, Viterbo
dc.contributor.author Gamboa Morán, Ricardo
dc.contributor.author Muro Ecca, Claudio Alberto
dc.contributor.author Moyano, Luz M.
dc.contributor.author Benavides, Victor
dc.contributor.author Flecker, Robert H.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author O'Neal, Seth E.
dc.date.accessioned 2019-01-25T16:03:20Z
dc.date.available 2019-01-25T16:03:20Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4763
dc.description.abstract BACKGROUND: Taenia solium, a parasite that affects humans and pigs, is the leading cause of preventable epilepsy in the developing world. Geographic hotspots of pigs testing positive for serologic markers of T. solium exposure have been observed surrounding the locations of human tapeworm carriers. This clustered pattern of seropositivity in endemic areas formed the basis for geographically targeted control interventions, which have been effective at reducing transmission. In this study, we further explore the spatial relationship between human tapeworm carriers and infected pigs using necroscopic examination as a quantitative gold-standard diagnostic to detect viable T. solium cyst infection in pigs. METHODOLOGY/PRINCIPAL FINDINGS: We performed necroscopic examinations on pigs from 7 villages in northern Peru to determine the number of viable T. solium cysts in each pig. Participating humans in the study villages were tested for T. solium tapeworm infection (i.e., taeniasis) with an ELISA coproantigen assay, and the distances from each pig to its nearest human tapeworm carrier were calculated. We assessed the relationship between proximity to a tapeworm carrier and the prevalence of light, moderate, and heavy cyst burden in pigs. The prevalence of pig infection was greatest within 50 meters of a tapeworm carrier and decreased monotonically as distance increased. Pigs living less than 50 meters from a human tapeworm carrier were 4.6 times more likely to be infected with at least one cyst than more distant pigs. Heavier cyst burdens, however, were not more strongly associated with proximity to tapeworm carriers than light cyst burdens. CONCLUSION/SIGNIFICANCE: Our study shows that human tapeworm carriers and pigs with viable T. solium cyst infection are geographically correlated in endemic areas. This finding supports control strategies that treat humans and pigs based on their proximity to other infected individuals. We did not, however, find sufficient evidence that heavier cyst burdens in pigs would serve as improved targets for geographically focused control interventions. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Antibodies, Helminth/blood en_US
dc.subject Carrier State/epidemiology/veterinary en_US
dc.subject Cysticercosis/epidemiology/veterinary en_US
dc.subject Cysts/parasitology/veterinary en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Logistic Models en_US
dc.subject Male en_US
dc.subject Peru/epidemiology en_US
dc.subject Spatial Analysis en_US
dc.subject Swine Diseases/epidemiology/parasitology en_US
dc.subject Swine/parasitology en_US
dc.subject Taenia solium/isolation & purification en_US
dc.title Spatial relationship between Taenia solium tapeworm carriers and necropsy cyst burden in pigs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0005536
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735

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