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Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile

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dc.contributor.author Lorenzo Bermejo, Justo
dc.contributor.author Boekstegers, Felix
dc.contributor.author Gonzalez Silos, Rosa
dc.contributor.author Marcelain, Katherine
dc.contributor.author Baez Benavides, Pablo
dc.contributor.author Barahona Ponce, Carol
dc.contributor.author Muller, Bettina
dc.contributor.author Ferreccio, Catterina
dc.contributor.author Koshiol, Jill
dc.contributor.author Fischer, Christine
dc.contributor.author Peil, Barbara
dc.contributor.author Sinsheimer, Janet
dc.contributor.author Fuentes Guajardo, Macarena
dc.contributor.author Barajas, Olga
dc.contributor.author Gonzalez-Jose, Rolando
dc.contributor.author Bedoya, Gabriel
dc.contributor.author Catira Bortolini, Maria
dc.contributor.author Canizales-Quinteros, Samuel
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Ruiz Linares, Andres
dc.contributor.author Rothhammer, Francisco
dc.date.accessioned 2019-01-25T16:03:21Z
dc.date.available 2019-01-25T16:03:21Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4768
dc.description.abstract Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1-4.3%, P = 6x10-27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Genetics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Genome-Wide Association Study en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Chile en_US
dc.subject Female en_US
dc.subject Gallbladder Neoplasms/genetics/mortality en_US
dc.subject Genetics, Population en_US
dc.subject Genome, Human en_US
dc.subject Genotype en_US
dc.subject Humans en_US
dc.subject Indians, North American/genetics en_US
dc.subject Latin America/epidemiology en_US
dc.subject Male en_US
dc.subject Risk Factors en_US
dc.title Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pgen.1006756
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1553-7404

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