The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age

Del Brutto, Oscar H.; García Lescano, Héctor Hugo; Del Brutto, Victor J.; Lama, Julio; Salgado, Perla; Zambrano, Mauricio; Issa, Naoum P.

dc.contributor.author	Del Brutto, Oscar H.
dc.contributor.author	Issa, Naoum P.
dc.contributor.author	Salgado, Perla
dc.contributor.author	Del Brutto, Victor J.
dc.contributor.author	Zambrano, Mauricio
dc.contributor.author	Lama, Julio
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2019-01-25T16:03:21Z
dc.date.available	2019-01-25T16:03:21Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4773
dc.description.abstract	Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case-control study design, residents in a rural village (Atahualpa) aged >/= 40 years with calcified NCC were identified as cases and paired to NCC-free individuals (control subjects) matched by age, sex, and level of education. Cases and control subjects underwent magnetic resonance imaging for hippocampal rating according to the Scheltens' scale for medial temporal atrophy and were interviewed to identify those with a clinical seizure disorder. The prevalence of hippocampal atrophy was compared between cases and control subjects by the use of the McNemar's test for correlated proportions. Seventy-five individuals with calcified NCC and their matched control subjects were included in the analysis. Hippocampal atrophy was noted in 26 (34.7%) cases and nine (12%) control subjects (odds ratio: 4.4; 95% confidence interval: 1.6-14.9, P < 0.0021). Stratification of pairs according to tertiles of age revealed an age-related trend in this association, which became significant only in those aged >/= 68 years (P = 0.027). Only five cases and one control had recurrent seizures (P = 0.221); three of these five cases had hippocampal atrophy, and the single control subject had normal hippocampi. This study confirms an association between NCC and hippocampal atrophy, and shows that this association is stronger in older age groups. This suggests that NCC-related hippocampal atrophy takes a long time to develop.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Aging	en_US
dc.subject	Adult	en_US
dc.subject	Aged	en_US
dc.subject	Atrophy/parasitology/pathology	en_US
dc.subject	Case-Control Studies	en_US
dc.subject	Female	en_US
dc.subject	Hippocampus/parasitology/pathology	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Middle Aged	en_US
dc.subject	Neurocysticercosis/parasitology/pathology	en_US
dc.subject	Odds Ratio	en_US
dc.subject	Risk Factors	en_US
dc.subject	Rural Population	en_US
dc.title	The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.16-0689
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645