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The FAS-670 AA genotype is associated with high proviral load in peruvian HAM/TSP patients

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dc.contributor.author Rosado, Jason
dc.contributor.author Morales, Sandra
dc.contributor.author Lopez, Giovanni
dc.contributor.author Clark, Daniel
dc.contributor.author Verdonck, Kristien
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Van Camp, Guy
dc.contributor.author Talledo Albujar, Michael John
dc.date.accessioned 2019-01-25T16:03:21Z
dc.date.available 2019-01-25T16:03:21Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/4776
dc.description.abstract Human T‐lymphotropic virus 1 (HTLV‐1) is the etiologic agent of the HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross‐linking of the FAS receptor expressed in viruses‐infected cells, and the ligand FASL presented by T‐cytotoxic cells. As HAM/TSP has been associated with high levels of proviral load (PVL), we hypothesized that certain genotypes of single‐nucleotide polymorphisms (SNPs) associated with a decreased protein expression of FAS and FASL could be risk factors for this disease. Three SNPs: FAS‐670A/G (rs1800682), FAS‐1377G/A (rs2234767), and FASL‐844C/T (rs763110) were analyzed in 73 HAM/TSP patients and 143 HTLV‐1 asymptomatic carriers. Ancestry informative markers were used to adjust for ethnicity through a principal component analysis. Gender, age, PVL, and the first three principal components were used as covariates. The FAS/FASL genotype distribution was not associated with HAM/TSP presence (P–> 0.05). The FAS‐670 AA genotype was associated with high PVL in comparison to FAS‐670 GG in HAM/TSP patients (P = 0.015), while in asymptomatic carriers low levels of PVL were observed (P > 0.05). Our findings suggest that rs1800682, rs2234767, and rs763110 genotypes are not associated with the presence of HAM/TSP, but that the FAS‐670 AA genotype can promote higher PVL values in HAM/TSP patients. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of Medical Virology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject antigens, CD95 en_US
dc.subject Genotype en_US
dc.subject HTLV-I-associated myelopathy-tropical spastic paraparesis en_US
dc.subject Human T-lymphotropic virus 1 en_US
dc.subject polymorphism, single nucleotide en_US
dc.subject Polymorphism, Single Nucleotide en_US
dc.subject proviral load en_US
dc.subject Viral Load en_US
dc.subject Cohort Studies en_US
dc.subject fas Receptor/genetics en_US
dc.subject Female en_US
dc.subject HTLV-I Infections/virology en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Proviruses/genetics en_US
dc.title The FAS-670 AA genotype is associated with high proviral load in peruvian HAM/TSP patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/jmv.24681
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.02
dc.relation.issn 1096-9071


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