Universidad Peruana Cayetano Heredia

The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru

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dc.contributor.author Kojima, Noah
dc.contributor.author Park, Hayoung
dc.contributor.author Konda, Kelika A.
dc.contributor.author Joseph Davey, Dvora L.
dc.contributor.author Bristow, Claire C.
dc.contributor.author Brown, Brandon
dc.contributor.author León Sandoval, Segundo Ramos
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Calvo, Gino M.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, Jeffrey D.
dc.date.accessioned 2019-01-25T16:03:22Z
dc.date.available 2019-01-25T16:03:22Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4780
dc.description.abstract BACKGROUND: Men who have sex with men (MSM) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in Peru. METHODS: From 2013 to 2014, MSM and transwomen seeking human immunodeficiency virus (HIV) or sexually transmitted infection (STI) testing and/or treatment were recruited into a 2-year observational cohort study to determine predictors of recently acquired syphilis infection (defined as a rapid plasma reagin [RPR] titer >/=1:16 and a reactive treponemal antibody test) in Lima, Peru. At baseline, interviewers collected sociodemographic, behavioral, and medical characteristics from participants. All cohort participants were tested for syphilis, HIV, Chlamydia trachomatis (CT), and Neisseria gonorrhoeae (NG) infection. Using cross-sectional analyses, bivariate and multivariate models were used to determine factors associated with recently acquired syphilis infection and calculate adjusted prevalence ratios. RESULTS: We recruited 401 participants, 312 MSM and 89 transwomen, with median ages of 29.0 and 32.5 years old (interquartile ranges: 23.3, 37.4 and 27.2, 39.5, respectively). The prevalence of recently acquired syphilis infection at baseline was 16.8% for MSM and 6.7% for transwomen. Among MSM and transwomen, 30.1 and 33.7% were infected with HIV, 18.6 and 24.7% were infected with CT, and 14.2 and 19.1% were infected with NG, respectively. Co-infection rates among MSM with recently acquired syphilis infection included: 44.2% with HIV, 40.4% with CT (32.7% with anal CT and 7.7% with pharyngeal CT), and 19.2% with NG (11.5% with anal NG and 7.7% with pharyngeal NG). Co-infection rates among transwomen with recently acquired syphilis infection included: 66.7% with HIV, 0% with CT, and 16.7% with anal NG. In multivariate analysis among the entire cohort, recently acquired syphilis infection was independently associated with younger age (adjusted prevalence ratio [aPR] = 0.96, 95% confidence interval [CI] = 0.93-0.99), receptive role during anal sex (aPR = 2.56, 95% CI = 1.05-6.25), prior HIV diagnosis (aPR = 1.70, 95% CI = 1.11-2.61), anal CT or NG infection (aPR = 1.69, 95% CI = 1.09-2.60), and prior syphilis diagnosis (aPR = 3.53, 95% CI = 2.20-5.68). CONCLUSIONS: We recruited a cohort of MSM and transwomen who had a high prevalence of recently acquired syphilis infection in Lima, Peru. Recently acquired syphilis infection was associated with socio-demographic characteristics, sexual risk, and sexually transmitted co-infections. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HIV en_US
dc.subject Homosexuality, Male en_US
dc.subject Human immunodeficiency virus en_US
dc.subject Men who have sex with men en_US
dc.subject MSM en_US
dc.subject Peru en_US
dc.subject Sexually transmitted infection en_US
dc.subject STI en_US
dc.subject Syphilis en_US
dc.subject Transgender Persons en_US
dc.subject Transwomen en_US
dc.subject Treponema Pallidum en_US
dc.subject Adult en_US
dc.subject Chlamydia Infections/complications/epidemiology en_US
dc.subject Chlamydia trachomatis en_US
dc.subject Cohort Studies en_US
dc.subject Coinfection/epidemiology en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Female en_US
dc.subject Gonorrhea/complications/epidemiology en_US
dc.subject HIV Infections/epidemiology en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Neisseria gonorrhoeae en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Risk Factors en_US
dc.subject Sexual Behavior en_US
dc.subject Syphilis/epidemiology en_US
dc.title The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12879-017-2332-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1471-2334


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