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Urbanization, mainly rurality, but not altitude is associated with dyslipidemia profiles

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dc.contributor.author Lazo-Porras, Maria
dc.contributor.author Bernabe-Ortiz, Antonio
dc.contributor.author Quispe, Renato
dc.contributor.author Málaga, German
dc.contributor.author Smeeth, Liam
dc.contributor.author Gilman, Robert H.
dc.contributor.author Checkley, William
dc.contributor.author Miranda, J. Jaime
dc.contributor.author CRONICAS Cohort Study Group
dc.date.accessioned 2019-01-25T16:20:55Z
dc.date.available 2019-01-25T16:20:55Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4789
dc.description.abstract BACKGROUND: Geographical and environmental features such as urbanization and altitude may influence individual's lipid profiles because of the diversity of human-environment interactions including lifestyles. OBJECTIVE: To characterize the association between altitude and urbanization and lipid profile among Peruvian adults aged ≥35 years. METHODS: Cross-sectional analysis of the CRONICAS Cohort Study. The outcomes of interest were 6 dyslipidemia traits: hypertriglyceridemia, high low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol (HDL-c), nonisolated low HDL-c, isolated low HDL-c, and high non-HDL-c. The exposures of interest were urbanization level (highly urban, urban, semi-urban, and rural) and altitude (high altitude vs sea level). Prevalence ratios (PRs) and 95% confidence intervals (95% CIs) were calculated using Poisson regression models with robust variance adjusting for potential confounders. RESULTS: Data from 3037 individuals, 48.5% males, mean age of 55.6 (standard deviation ±12.7) years, were analyzed. The most common dyslipidemia pattern was high non-HDL-c with a prevalence of 88.0% (95% CI: 84.9%-90.7%) in the rural area and 96.0% (95% CI: 94.5%-97.1%) in the semi-urban area. Relative to the highly urban area, living in rural areas was associated with a lower prevalence of hypertriglyceridemia (PR = 0.75; 95% CI: 0.56-0.99) and high non-HDL-c (PR = 0.96; 95% CI: 0.93-0.99), whereas living in semi-urban areas was associated with higher prevalence high low-density lipoprotein cholesterol (PR = 1.37; 95% CI: 1.11-1.67). Compared with sea level areas, high-altitude areas had lower prevalence of high non-HDL-c (PR = 0.97; 95% CI: 0.95-0.99). CONCLUSION: Urbanization but not altitude was associated to several dyslipidemia traits, with the exception of high non-HDL-c in high altitude settings. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1933-2874
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Cohort Studies en_US
dc.subject Altitude en_US
dc.subject Environment en_US
dc.subject Body Mass Index en_US
dc.subject Urbanization en_US
dc.subject Dyslipidemia en_US
dc.subject Rurality en_US
dc.subject Lipids/blood en_US
dc.subject Rural Population/statistics & numerical data en_US
dc.subject Urbanization en_US
dc.subject Dyslipidemias/blood/epidemiology en_US
dc.title Urbanization, mainly rurality, but not altitude is associated with dyslipidemia profiles en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jacl.2017.06.016
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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