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Ventilatory Cycle Measurements and Loop Gain in Central Apnea in Mining Drivers Exposed to Intermittent Altitude

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dc.contributor.author Rey de Castro, Jorge
dc.contributor.author Liendo, Alicia
dc.contributor.author Ortiz, Oswaldo
dc.contributor.author Rosales-Mayor, Edmundo
dc.contributor.author Liendo, Cesar
dc.date.accessioned 2019-01-25T16:20:56Z
dc.date.available 2019-01-25T16:20:56Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4795
dc.description.abstract STUDY OBJECTIVES: By measuring the apnea length, ventilatory phase, respiratory cycle length, and loop gain, we can further characterize the central apneas of high altitude (CAHA). METHODS: Sixty-three drivers of all-terrain vehicles, working in a Peruvian mine located at 2,020 meters above sea level (MASL), were evaluated. A respiratory polygraph was performed in the first night they slept at high altitude. None of the subjects were exposed to oxygen during the test or acetazolamide in the preceding days of the test. RESULTS: Sixty-three respiratory polygraphs were performed, and 59 were considered for analysis. Forty-six (78%) were normal, 6 (10%) had OSA, and 7 (12%) had CAHA. Key data from subjects include: residing altitude: 341 +/- 828 MASL, Lake Louise scoring: 0.4 +/- 0.8, Epworth score: 3.4 +/- 2.7, apneahypopnea index: 35.7 +/- 19.3, CA index: 13.4 +/- 14.2, CA length: 14.4 +/- 3.6 sec, ventilatory length: 13.5 +/- 2.9 sec, cycle length: 26.5 +/- 4.0 sec, ventilatory length/CA length ratio 0.9 +/- 0.3 and circulatory delay 13.3 +/- 2.9 sec. Duty ratio media [ventilatory duration/cycle duration] was 0.522 +/- 0 0.128 [0.308-0.700] and loop gain was calculated from the duty ratio utilizing this formula: LG = 2pi / [(2piDR-sin(2piDR)]. All subjects have a high loop gain media 2.415 +/- 1.761 [1.175-6.260]. Multiple correlations were established with loop gain values, but the only significant correlation detected was between central apnea index and loop gain. CONCLUSIONS: Twelve percent of the studied population had CAHA. Measurements of respiratory cycle in workers with CAHA are more similar to idiopathic central apneas rather than Hunter-Cheyne-Stokes respiration. Also, there was a high degree of correlation between severity of central apnea and the degree of loop gain. The abnormal breathing patterns in those subjects could affect the sleep quality and potentially increase the risk for work accidents. en_US
dc.language.iso eng
dc.publisher American Academy of Sleep Medicine
dc.relation.ispartofseries Journal of Clinical Sleep Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject Automobile Driving en_US
dc.subject central apnea en_US
dc.subject driver en_US
dc.subject high altitude en_US
dc.subject loop gain en_US
dc.subject Mining en_US
dc.subject sleep en_US
dc.subject Adult en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Humans en_US
dc.subject Off-Road Motor Vehicles en_US
dc.subject Peru en_US
dc.subject Polysomnography en_US
dc.subject Sleep Apnea, Central/diagnosis/physiopathology en_US
dc.subject Time Factors en_US
dc.title Ventilatory Cycle Measurements and Loop Gain in Central Apnea in Mining Drivers Exposed to Intermittent Altitude en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5664/jcsm.6380
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1550-9397


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