Universidad Peruana Cayetano Heredia

Virulence and Antimicrobial Resistance in Campylobacter spp. from a Peruvian Pediatric Cohort

Mostrar el registro sencillo del ítem

dc.contributor.author Lluque, Angela
dc.contributor.author Riveros Ramirez, Maribel Denise
dc.contributor.author Prada, Ana
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Ruiz, Joaquim
dc.date.accessioned 2019-01-25T16:20:56Z
dc.date.available 2019-01-25T16:20:56Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4796
dc.description.abstract The presence of virulence factors (VFs) and mechanisms of quinolones and macrolide resistance was analyzed in Campylobacter spp. from a pediatric cohort study in Lima. In 149 isolates (39 Campylobacter jejuni and 24 Campylobacter coli from diarrheic cases; 57 C. jejuni and 29 C. coli from controls), the presence of the cdtABC and cadF genes and iam marker was established. Nalidixic acid, ciprofloxacin, erythromycin, and azithromycin susceptibilities were established in 115 isolates and tetracycline-susceptibility was established in 100 isolates. The presence of mutations in the gyrA, parC, and 23S rRNA genes was determined. The cadF gene and all genes from the cdtABC operon were significantly more frequent among C. jejuni (P < 0.0001); the iam marker was more frequent in C. coli (P < 0.0001). No differences were observed in VFs between cases and controls. Almost all isolates were tetracycline-resistant; nalidixic acid and ciprofloxacin resistance reached levels of 90.4% and 88.7%, respectively. Resistance to macrolides was 13% (C. jejuni 4.3%; C. coli 26.1%). Resistance to ciprofloxacin was related to GyrA Thr86 substitutions, while 13 of 15 macrolide-resistant isolates possessed a 23S rRNA mutation (A2075G). Differences in the presence of VFs and alarming levels of resistance to tested antimicrobial agents were observed among C. jejuni and C. coli. en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartofseries Scientifica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Virulence en_US
dc.subject Antimicrobial Resistance en_US
dc.subject Campylobacter spp. en_US
dc.title Virulence and Antimicrobial Resistance in Campylobacter spp. from a Peruvian Pediatric Cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1155/2017/7848926
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.00.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.07.01
dc.relation.issn 2090-908X


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas