Universidad Peruana Cayetano Heredia

Worrisome high frequency of extended-spectrum beta-lactamase-producing Escherichia coli in community-acquired urinary tract infections: a case-control study

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dc.contributor.author Castillo-Tokumori, Franco
dc.contributor.author Irey-Salgado, Claudia
dc.contributor.author Málaga Rodríguez, Germán Javier
dc.date.accessioned 2019-01-25T16:20:56Z
dc.date.available 2019-01-25T16:20:56Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4800
dc.description.abstract OBJECTIVES: There has been a sustained and dramatic increase in community-acquired urinary tract infections (CA-UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria over recent years. Despite this, no studies have been performed in low- or middle-income countries. The main objective of this case-control study was to describe ESBL CA-UTI and its risk factors. METHODS: Outpatients with CA-UTI seen at the Hospital Cayetano Heredia during 2015 were identified. Patients were contacted by telephone. After consent had been obtained, a questionnaire concerning previously identified risk factors was applied. Univariate and multivariate analyses were conducted using Stata version 13. RESULTS: The overall frequency of ESBL-producing Escherichia coli was 40.85%. Sixty-seven cases and 105 controls were included in this study. The following main risk factors were identified on multivariate analysis: previous antibiotic use (odds ratio (OR) 3.09), previous hospitalization (OR 2.92), and previous surgery (OR 2.75). Chronic corticosteroid use (OR 24.32, 95% confidence interval 2.39-246.92) was also identified as a risk factor. CONCLUSIONS: ESBL E. coli accounted for more than 40% of CA-UTIs during 2015. A history of previous hospitalization, surgery, and antibiotic use should be considered when treating this type of infection. Action should be taken to confirm these worrisome results and avoid the major consequences for public health. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Anti-Bacterial Agents/therapeutic use en_US
dc.subject beta-Lactamases/biosynthesis en_US
dc.subject Case-Control Studies en_US
dc.subject Community-acquired infection en_US
dc.subject Community-Acquired Infections/drug therapy/epidemiology/microbiology en_US
dc.subject Drug Resistance, Multiple, Bacterial en_US
dc.subject ESBL en_US
dc.subject Escherichia coli en_US
dc.subject Escherichia coli Infections/epidemiology/microbiology en_US
dc.subject Escherichia coli/drug effects/isolation & purification/metabolism en_US
dc.subject Female en_US
dc.subject Hospitalization en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Multivariate Analysis en_US
dc.subject Peru/epidemiology en_US
dc.subject Public Health en_US
dc.subject Risk Factors en_US
dc.subject Surveys and Questionnaires en_US
dc.subject Urinary tract infection en_US
dc.subject Urinary Tract Infections/drug therapy/epidemiology/microbiology en_US
dc.title Worrisome high frequency of extended-spectrum beta-lactamase-producing Escherichia coli in community-acquired urinary tract infections: a case-control study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijid.2016.12.007
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1878-3511


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