Universidad Peruana Cayetano Heredia

Correlates of early pregnancy serum brain-derived neurotrophic factor in a Peruvian population

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dc.contributor.author Yang, N.
dc.contributor.author Levey, E.
dc.contributor.author Gelaye, B.
dc.contributor.author Zhong, Q. Y.
dc.contributor.author Rondon, M. B.
dc.contributor.author Sanchez, S. E.
dc.contributor.author Williams, M. A.
dc.date.accessioned 2019-01-25T16:20:58Z
dc.date.available 2019-01-25T16:20:58Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4816
dc.description.abstract Knowledge about factors that influence serum brain-derived neurotrophic factor (BDNF) concentrations during early pregnancy is lacking. The aim of the study is to examine the correlates of early pregnancy serum BDNF concentrations. A total of 982 women attending prenatal care clinics in Lima, Peru, were recruited in early pregnancy. Pearson's correlation coefficient was calculated to evaluate the relation between BDNF concentrations and continuous covariates. Analysis of variance and generalized linear models were used to compare the unadjusted and adjusted BDNF concentrations according to categorical variables. Multivariable linear regression models were applied to determine the factors that influence early pregnancy serum BDNF concentrations. In bivariate analysis, early pregnancy serum BDNF concentrations were positively associated with maternal age (r = 0.16, P < 0.001) and early pregnancy body mass index (BMI) (r = 0.17, P < 0.001), but inversely correlated with gestational age at sample collection (r = -0.21, P < 0.001) and C-reactive protein (CRP) concentrations (r = -0.07, P < 0.05). In the multivariable linear regression model, maternal age (beta = 0.11, P = 0.001), early pregnancy BMI (beta = 1.58, P < 0.001), gestational age at blood collection (beta = -0.33, P < 0.001), and serum CRP concentrations (beta = -0.57, P = 0.002) were significantly associated with early pregnancy serum BDNF concentrations. Participants with moderate antepartum depressive symptoms (Patient Health Questionnaire-9 (PHQ-9) score ae<yen> 10) had lower serum BDNF concentrations compared with participants with no/mild antepartum depressive symptoms (PHQ-9 score < 10). Maternal age, early pregnancy BMI, gestational age, and the presence of moderate antepartum depressive symptoms were statistically significantly associated with early pregnancy serum BDNF concentrations in low-income Peruvian women. Biological changes of CRP during pregnancy may affect serum BDNF concentrations. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Archives of Women's Mental Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject overweight en_US
dc.subject depression en_US
dc.subject inflammation en_US
dc.subject Psychiatry en_US
dc.subject cells en_US
dc.subject protein en_US
dc.subject women en_US
dc.subject plasma en_US
dc.subject individuals en_US
dc.subject Early pregnancy en_US
dc.subject Antepartum depressive symptoms en_US
dc.subject Brain-derived neurotrophic factor en_US
dc.subject C-reactive en_US
dc.subject embryo development en_US
dc.subject factor bdnf en_US
dc.subject receptors en_US
dc.title Correlates of early pregnancy serum brain-derived neurotrophic factor in a Peruvian population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s00737-017-0759-0
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.24
dc.relation.issn 1435-1102


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