Universidad Peruana Cayetano Heredia

Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru

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dc.contributor.author Mullins, K. E.
dc.contributor.author Hang, J.
dc.contributor.author Clifford, R. J.
dc.contributor.author Onmus-Leone, F.
dc.contributor.author Yang, Y.
dc.contributor.author Jiang, J.
dc.contributor.author Leguia, M.
dc.contributor.author Kasper, M. R.
dc.contributor.author Maguiña Vargas, Ciro
dc.contributor.author Lesho, E. P.
dc.contributor.author Jarman, R. G.
dc.contributor.author Richards, A.
dc.contributor.author Blazes, D.
dc.date.accessioned 2019-01-25T16:20:58Z
dc.date.available 2019-01-25T16:20:58Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4821
dc.description.abstract The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living in Caraz, Peru, during a clinical trial of treatment for bartonellosis. Three B. ancashensis strains were analyzed by using whole-genome restriction mapping and high throughput pyrosequencing. Genome-wide comparative analysis of Bartonella species showed that B. ancashensis has features seen in modern and ancient lineages of Bartonella species and is more related to B. bacilliformis. The divergence between B. ancashensis and B. bacilliformis is much greater than what is seen between known Bartonella genetic lineages. In addition, B. ancashensis contains type IV secretion system proteins, which are not present in B. bacilliformis. Whole-genome analysis indicates that B. ancashensis might represent a distinct Bartonella lineage phylogenetically related to B. bacilliformis. en_US
dc.language.iso eng
dc.publisher Centers for Disease Control and Prevention
dc.relation.ispartofseries Emerging Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject bacteremia en_US
dc.subject endocarditis en_US
dc.subject Infectious Diseases en_US
dc.subject Immunology en_US
dc.subject infection en_US
dc.subject population en_US
dc.subject diversity en_US
dc.subject bacilliformis en_US
dc.subject natural-history en_US
dc.subject quintana en_US
dc.title Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3201/eid2303.161476
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1080-6059


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