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Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients

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dc.contributor.author Gimbrone, N. T.
dc.contributor.author Sarcar, B.
dc.contributor.author Gordian, E. R.
dc.contributor.author Rivera, J. I.
dc.contributor.author Lopez, C.
dc.contributor.author Yoder, S. J.
dc.contributor.author Teer, J. K.
dc.contributor.author Welsh, E. A.
dc.contributor.author Chiaporri, A. A.
dc.contributor.author Schabath, M. B.
dc.contributor.author Reuther, G. W.
dc.contributor.author Dutil, J.
dc.contributor.author Garcia, M.
dc.contributor.author Ventosilla-Villanueva, R.
dc.contributor.author Vera-Valdivia, L.
dc.contributor.author Yabar-Berrocal, A.
dc.contributor.author Motta-Guerrero, R.
dc.contributor.author Santiago-Cardona, P. G.
dc.contributor.author Munoz-Antonia, T.
dc.contributor.author Cress, W. D.
dc.date.accessioned 2019-01-25T16:36:28Z
dc.date.available 2019-01-25T16:36:28Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4845
dc.description.abstract Background: This study examined lung cancer tumor samples from 163 Hispanic patients. Tumor-derived DNA was subjected to targeted-exome sequencing and ancestry analysis. Results: Among adenocarcinomas (n=120) in the Hispanic cohort, 31% had EGFR mutations, compared to 17% in a non-Hispanic White (NHW) control group (p < 0.001). A rare exon 19 mutation, W731R, was identified that conferred resistance to both erlotinib and AZD9291. KRAS (20% vs. 38%; p=0.002) and STK11 (8% vs. 16%; p=0.065) mutations occurred at lower frequency, and mutations in TP53 occurred at similar frequency (46% vs. 40%; p=0.355) in Hispanic and NHW patients, respectively. Within Hispanics, Indigenous American ancestry associated with a low rate of TP53 mutations (p=0.009) and may also associate with an elevated rate of EGFR mutations. Conclusions: We conclude that mutations in Hispanic lung adenocarcinoma patients differ in frequency from those in NHWs associated with their Indigenous American ancestry. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Thoracic Oncology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Respiratory System en_US
dc.subject Oncology en_US
dc.title Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jtho.2017.06.041
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.21
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1556-1380


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