Universidad Peruana Cayetano Heredia
Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients
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| dc.contributor.author | Gimbrone, N. T. | |
| dc.contributor.author | Sarcar, B. | |
| dc.contributor.author | Gordian, E. R. | |
| dc.contributor.author | Rivera, J. I. | |
| dc.contributor.author | Lopez, C. | |
| dc.contributor.author | Yoder, S. J. | |
| dc.contributor.author | Teer, J. K. | |
| dc.contributor.author | Welsh, E. A. | |
| dc.contributor.author | Chiaporri, A. A. | |
| dc.contributor.author | Schabath, M. B. | |
| dc.contributor.author | Reuther, G. W. | |
| dc.contributor.author | Dutil, J. | |
| dc.contributor.author | Garcia, M. | |
| dc.contributor.author | Ventosilla-Villanueva, R. | |
| dc.contributor.author | Vera-Valdivia, L. | |
| dc.contributor.author | Yabar-Berrocal, A. | |
| dc.contributor.author | Motta-Guerrero, R. | |
| dc.contributor.author | Santiago-Cardona, P. G. | |
| dc.contributor.author | Munoz-Antonia, T. | |
| dc.contributor.author | Cress, W. D. | |
| dc.date.accessioned | 2019-01-25T16:36:28Z | |
| dc.date.available | 2019-01-25T16:36:28Z | |
| dc.date.issued | 2017 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/4845 | |
| dc.description.abstract | Background: This study examined lung cancer tumor samples from 163 Hispanic patients. Tumor-derived DNA was subjected to targeted-exome sequencing and ancestry analysis. Results: Among adenocarcinomas (n=120) in the Hispanic cohort, 31% had EGFR mutations, compared to 17% in a non-Hispanic White (NHW) control group (p < 0.001). A rare exon 19 mutation, W731R, was identified that conferred resistance to both erlotinib and AZD9291. KRAS (20% vs. 38%; p=0.002) and STK11 (8% vs. 16%; p=0.065) mutations occurred at lower frequency, and mutations in TP53 occurred at similar frequency (46% vs. 40%; p=0.355) in Hispanic and NHW patients, respectively. Within Hispanics, Indigenous American ancestry associated with a low rate of TP53 mutations (p=0.009) and may also associate with an elevated rate of EGFR mutations. Conclusions: We conclude that mutations in Hispanic lung adenocarcinoma patients differ in frequency from those in NHWs associated with their Indigenous American ancestry. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartofseries | Journal of Thoracic Oncology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Respiratory System | en_US |
| dc.subject | Oncology | en_US |
| dc.title | Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1016/j.jtho.2017.06.041 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.21 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.07 | |
| dc.relation.issn | 1556-1380 |
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