Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients

Cress, W. D.; Reuther, G. W.; Rivera, J. I.; Gimbrone, N. T.; Gordian, E. R.; Santiago-Cardona, P. G.; Ventosilla-Villanueva, R.; Munoz-Antonia, T.; Chiaporri, A. A.; Lopez, C.; Garcia, M.; Yoder, S. J.; Vera-Valdivia, L.; Welsh, E. A.; Yabar-Berrocal, A.; Dutil, J.; Motta-Guerrero, R.; Sarcar, B.; Teer, J. K.; Schabath, M. B.

dc.contributor.author	Gimbrone, N. T.
dc.contributor.author	Sarcar, B.
dc.contributor.author	Gordian, E. R.
dc.contributor.author	Rivera, J. I.
dc.contributor.author	Lopez, C.
dc.contributor.author	Yoder, S. J.
dc.contributor.author	Teer, J. K.
dc.contributor.author	Welsh, E. A.
dc.contributor.author	Chiaporri, A. A.
dc.contributor.author	Schabath, M. B.
dc.contributor.author	Reuther, G. W.
dc.contributor.author	Dutil, J.
dc.contributor.author	Garcia, M.
dc.contributor.author	Ventosilla-Villanueva, R.
dc.contributor.author	Vera-Valdivia, L.
dc.contributor.author	Yabar-Berrocal, A.
dc.contributor.author	Motta-Guerrero, R.
dc.contributor.author	Santiago-Cardona, P. G.
dc.contributor.author	Munoz-Antonia, T.
dc.contributor.author	Cress, W. D.
dc.date.accessioned	2019-01-25T16:36:28Z
dc.date.available	2019-01-25T16:36:28Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4845
dc.description.abstract	Background: This study examined lung cancer tumor samples from 163 Hispanic patients. Tumor-derived DNA was subjected to targeted-exome sequencing and ancestry analysis. Results: Among adenocarcinomas (n=120) in the Hispanic cohort, 31% had EGFR mutations, compared to 17% in a non-Hispanic White (NHW) control group (p < 0.001). A rare exon 19 mutation, W731R, was identified that conferred resistance to both erlotinib and AZD9291. KRAS (20% vs. 38%; p=0.002) and STK11 (8% vs. 16%; p=0.065) mutations occurred at lower frequency, and mutations in TP53 occurred at similar frequency (46% vs. 40%; p=0.355) in Hispanic and NHW patients, respectively. Within Hispanics, Indigenous American ancestry associated with a low rate of TP53 mutations (p=0.009) and may also associate with an elevated rate of EGFR mutations. Conclusions: We conclude that mutations in Hispanic lung adenocarcinoma patients differ in frequency from those in NHWs associated with their Indigenous American ancestry.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Journal of Thoracic Oncology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Respiratory System	en_US
dc.subject	Oncology	en_US
dc.title	Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.jtho.2017.06.041
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.21
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn	1556-1380