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Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas

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dc.contributor.author Martinez-Martinez, M.
dc.contributor.author Mosqueda-Taylor, A.
dc.contributor.author Carlos-Bregni, R.
dc.contributor.author Pires, F. R.
dc.contributor.author Delgado-Azanero, W.
dc.contributor.author Neves-Silva, R.
dc.contributor.author Aldape-Barrios, B.
dc.contributor.author Almeida, O. P. D.
dc.date.accessioned 2019-01-25T16:36:29Z
dc.date.available 2019-01-25T16:36:29Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4849
dc.description.abstract Background: This study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). Material and Methods: Fifteen cases of AM and 9 AC were submitted to hematoxilin and eosin (H&E) and immunohistochemical analysis with the following antibodies: cytokeratins 5,7,8,14 and 19, Ki-67, p53, p63 and the cellular adhesion molecules CD138 (Syndecan-1), E-cadherin and beta-catenin. The mean score of the expression of Ki-67 and p53 labelling index (LIs) were compared between the groups using the t test. A value of p<0.05 was considered to be statistically significant. Results: All cases were positive for CKs 5, 14 and 19, but negative for CKs 7 and 8. CKs 5 and 19 were positive mainly in the central regions of the ameloblastic islands, while the expression in AC was variable in intensity and localization. CK14 was also variably expressed in both AM and AC. Ki-67 (P=.001) and p53 (P=.004) immuno-expression was higher in AC. All cases were positive for p63, but values were higher in AC. CD138 was mainly expressed in peripheral cells of AM, with a weak positivity in the central areas, while it was positive in most areas of ACs, except in less differentiated regions, where expression was decreased or lost. E-cadherin and beta-catenin were weakly positive in both AM and AC. Conclusions: These results shows that Ki-67, p53 and p63 expression was higher in AC as compared to AM, suggesting that these markers can be useful when considering diagnosis of malignancy, and perhaps could play a role in malignant transformation of AM. Pattern of expression of CKs 5 and 19 in AC were different to those found in AM, suggesting genetic alterations of these proteins in malignant cells. It was confirmed that CK19 is a good marker for benign odontogenic tumors, such as AM, but it is variably expressed in malignant cases. en_US
dc.language.iso eng
dc.publisher Medicina Oral
dc.relation.ispartof urn:issn:1698-6946
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Ameloblastoma en_US
dc.subject Dentistry, Oral Surgery & Medicine en_US
dc.subject expression en_US
dc.subject ameloblastic carcinoma en_US
dc.subject catenin en_US
dc.subject cytokeratins en_US
dc.subject e-cadherin en_US
dc.subject gene en_US
dc.subject immunohistochemistry en_US
dc.subject ki-67 en_US
dc.subject odontogenic en_US
dc.subject odontogenic-tumors en_US
dc.subject p63 en_US
dc.subject syndecan-1 cd138 en_US
dc.subject tumors en_US
dc.title Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4317/medoral.21901
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.11

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