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The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries

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dc.contributor.author McGrath, J. J.
dc.contributor.author McLaughlin, K. A.
dc.contributor.author Saha, S.
dc.contributor.author Aguilar-Gaxiola, S.
dc.contributor.author Al-Hamzawi, A.
dc.contributor.author Alonso, J.
dc.contributor.author Bruffaerts, R.
dc.contributor.author de Girolamo, G.
dc.contributor.author de Jonge, P.
dc.contributor.author Esan, O.
dc.contributor.author Florescu, S.
dc.contributor.author Gureje, O.
dc.contributor.author Haro, J. M.
dc.contributor.author Hu, C.
dc.contributor.author Karam, E. G.
dc.contributor.author Kovess-Masfety, V.
dc.contributor.author Lee, S.
dc.contributor.author Lepine, J. P.
dc.contributor.author Lim, C. C. W.
dc.contributor.author Medina-Mora, M. E.
dc.contributor.author Mneimneh, Z.
dc.contributor.author Pennell, B. E.
dc.contributor.author Piazza, M.
dc.contributor.author Posada-Villa, J.
dc.contributor.author Sampson, N.
dc.contributor.author Viana, M. C.
dc.contributor.author Xavier, M.
dc.contributor.author Bromet, E. J.
dc.contributor.author Kendler, K. S.
dc.contributor.author Kessler, R. C.
dc.contributor.author WHO World Mental Health Survey
dc.date.accessioned 2019-01-25T16:36:29Z
dc.date.available 2019-01-25T16:36:29Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4857
dc.description.abstract Background. Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. Method. We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models. Results. Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [ odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9-2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6-20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF). Conclusions. Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartof urn:issn:1469-8978
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Psychiatry en_US
dc.subject Psychology en_US
dc.subject comorbidity survey replication en_US
dc.subject posttraumatic-stress-disorder en_US
dc.subject age-of-onset en_US
dc.subject adult psychiatric-disorders en_US
dc.subject birth cohort en_US
dc.subject Childhood adversity en_US
dc.subject delusional-like experiences en_US
dc.subject discrete-time survival analysis en_US
dc.subject dsm-iv-disorders en_US
dc.subject emotion regulation en_US
dc.subject experiences en_US
dc.subject functioning en_US
dc.subject general-population en_US
dc.subject maladaptive family en_US
dc.subject mental-health survey en_US
dc.subject population attributable risk proportion en_US
dc.subject psychotic en_US
dc.subject World Mental Health survey en_US
dc.title The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/s0033291716003263
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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