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Characterisation of the first KPC-2-producing Klebsiella pneumoniae ST340 from Peru

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dc.contributor.author Horna, Gertrudis
dc.contributor.author Velasquez, Jorge
dc.contributor.author Fernandez, Nathaly
dc.contributor.author Tamariz, Jesus
dc.contributor.author Ruiz, Joaquim
dc.date.accessioned 2019-01-25T16:59:36Z
dc.date.available 2019-01-25T16:59:36Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4877
dc.description.abstract OBJECTIVES: The aim of this study was to characterise a KPC-carrying Klebsiella pneumoniae isolate from a Peruvian hospital setting. METHODS: The identity of the isolate was confirmed by amplification and sequencing of the 16S rRNA gene, and the antibiotic resistance profile was determined by disk diffusion and automated methods The sequence type (ST) and phylogenetic group were established by PCR. The presence of different beta-lactamase genes was determined, including blaMBL, blaKPC, blaCTX-M, blaSHV, blaOXA-1-like, blaOXA-2-like, blaOXA-5-like, blaOXA-48-like and blaTEM and up to six different plasmid-encoded AmpC genes as well as class 1 integrons. The conjugability of beta-lactam resistance was assessed by conjugation. RESULTS: The isolate was confirmed to be K. pneumoniae classified as belonging to the KpI phylogenetic group within ST340, which belongs to the high-risk clonal complex 258 (CC258). The isolate was resistant to all beta-lactam agents tested, with only the presence of a non-conjugative blaKPC-2 gene being detected and carried in a non-classical genetic structure. CONCLUSIONS: This is the first description of a member of CC258 and of a blaKPC-2 gene in Peru. Intensive surveillance is needed to determine the relevance of both in this area. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:2213-7173
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject South America en_US
dc.subject beta-Lactamase en_US
dc.subject Genetic environment en_US
dc.subject KPC en_US
dc.title Characterisation of the first KPC-2-producing Klebsiella pneumoniae ST340 from Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jgar.2016.12.011
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01

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