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Epidemiology of systemic lupus erythematosus

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dc.contributor.author Pons-Estel, Guillermo J.
dc.contributor.author Ugarte-Gil, Manuel F.
dc.contributor.author Alarcon, Graciela S.
dc.date.accessioned 2019-01-25T16:59:38Z
dc.date.available 2019-01-25T16:59:38Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4903
dc.description.abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is a disease distributed worldwide, which occurs in both genders, and across racial/ethnic and age groups; however, higher rates are observed in adults, in women and in non-Caucasians. Genetic, environmental, sociodemographic and methodological issues are responsible not only for these differences but for the variable course and outcome of the disease. Non-Caucasians have a more severe disease with a higher risk for early mortality and damage accrual. Males also have a more severe disease; however, a negative impact of male gender on lupus outcomes has not been firmly established. Childhood-onset is associated with a more severe disease; moreover, it is also associated with higher damage and diminished survival; finally, late-onset lupus is mild but it is associated with higher damage accrual and a diminished survival. Areas covered: In this review, we discuss the incidence and prevalence of SLE, the impact of age, gender and race/ethnicity in SLE and in the survival of those affected. Expert commentary: Age, gender and race/ethnicity impact disease expression in SLE patients; despite improvements in survival, mortality in SLE remains almost three times higher than in the general population. en_US
dc.language.iso eng
dc.publisher Taylor & Francis
dc.relation.ispartof urn:issn:1744-8409
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Survival Analysis en_US
dc.subject Risk Factors en_US
dc.subject Prevalence en_US
dc.subject Incidence en_US
dc.subject Disease Progression en_US
dc.subject age en_US
dc.subject Age Factors en_US
dc.subject Continental Population Groups en_US
dc.subject epidemiology en_US
dc.subject gender en_US
dc.subject incidence en_US
dc.subject prevalence en_US
dc.subject race /ethnicity en_US
dc.subject Sex Factors en_US
dc.subject survival /mortality en_US
dc.subject Systemic lupus erythematosus en_US
dc.subject Age of Onset en_US
dc.subject Lupus Erythematosus, Systemic/epidemiology/mortality en_US
dc.subject United States/epidemiology en_US
dc.title Epidemiology of systemic lupus erythematosus en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1080/1744666X.2017.1327352
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03

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