dc.contributor.author |
Pons-Estel, Guillermo J. |
|
dc.contributor.author |
Ugarte Gil, Manuel Francisco |
|
dc.contributor.author |
Alarcón, Graciela S. |
|
dc.date.accessioned |
2019-01-25T16:59:38Z |
|
dc.date.available |
2019-01-25T16:59:38Z |
|
dc.date.issued |
2017 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/4903 |
|
dc.description.abstract |
INTRODUCTION: Systemic lupus erythematosus (SLE) is a disease distributed worldwide, which occurs in both genders, and across racial/ethnic and age groups; however, higher rates are observed in adults, in women and in non-Caucasians. Genetic, environmental, sociodemographic and methodological issues are responsible not only for these differences but for the variable course and outcome of the disease. Non-Caucasians have a more severe disease with a higher risk for early mortality and damage accrual. Males also have a more severe disease; however, a negative impact of male gender on lupus outcomes has not been firmly established. Childhood-onset is associated with a more severe disease; moreover, it is also associated with higher damage and diminished survival; finally, late-onset lupus is mild but it is associated with higher damage accrual and a diminished survival. Areas covered: In this review, we discuss the incidence and prevalence of SLE, the impact of age, gender and race/ethnicity in SLE and in the survival of those affected. Expert commentary: Age, gender and race/ethnicity impact disease expression in SLE patients; despite improvements in survival, mortality in SLE remains almost three times higher than in the general population. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Taylor and Francis |
|
dc.relation.ispartofseries |
Expert Review of Clinical Immunology |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Female |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
Male |
en_US |
dc.subject |
Survival Analysis |
en_US |
dc.subject |
Risk Factors |
en_US |
dc.subject |
Prevalence |
en_US |
dc.subject |
Incidence |
en_US |
dc.subject |
Disease Progression |
en_US |
dc.subject |
age |
en_US |
dc.subject |
Age Factors |
en_US |
dc.subject |
Continental Population Groups |
en_US |
dc.subject |
epidemiology |
en_US |
dc.subject |
gender |
en_US |
dc.subject |
incidence |
en_US |
dc.subject |
prevalence |
en_US |
dc.subject |
race /ethnicity |
en_US |
dc.subject |
Sex Factors |
en_US |
dc.subject |
survival /mortality |
en_US |
dc.subject |
Systemic lupus erythematosus |
en_US |
dc.subject |
Age of Onset |
en_US |
dc.subject |
Lupus Erythematosus, Systemic/epidemiology/mortality |
en_US |
dc.subject |
United States/epidemiology |
en_US |
dc.title |
Epidemiology of systemic lupus erythematosus |
en_US |
dc.type |
info:eu-repo/semantics/review |
|
dc.identifier.doi |
https://doi.org/10.1080/1744666X.2017.1327352 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.01.03 |
|
dc.relation.issn |
1744-8409 |
|