Epidemiology of systemic lupus erythematosus

Ugarte Gil, Manuel Francisco; Pons-Estel, Guillermo J.; Alarcón, Graciela S.

dc.contributor.author	Pons-Estel, Guillermo J.
dc.contributor.author	Ugarte Gil, Manuel Francisco
dc.contributor.author	Alarcón, Graciela S.
dc.date.accessioned	2019-01-25T16:59:38Z
dc.date.available	2019-01-25T16:59:38Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4903
dc.description.abstract	INTRODUCTION: Systemic lupus erythematosus (SLE) is a disease distributed worldwide, which occurs in both genders, and across racial/ethnic and age groups; however, higher rates are observed in adults, in women and in non-Caucasians. Genetic, environmental, sociodemographic and methodological issues are responsible not only for these differences but for the variable course and outcome of the disease. Non-Caucasians have a more severe disease with a higher risk for early mortality and damage accrual. Males also have a more severe disease; however, a negative impact of male gender on lupus outcomes has not been firmly established. Childhood-onset is associated with a more severe disease; moreover, it is also associated with higher damage and diminished survival; finally, late-onset lupus is mild but it is associated with higher damage accrual and a diminished survival. Areas covered: In this review, we discuss the incidence and prevalence of SLE, the impact of age, gender and race/ethnicity in SLE and in the survival of those affected. Expert commentary: Age, gender and race/ethnicity impact disease expression in SLE patients; despite improvements in survival, mortality in SLE remains almost three times higher than in the general population.	en_US
dc.language.iso	eng
dc.publisher	Taylor and Francis
dc.relation.ispartofseries	Expert Review of Clinical Immunology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Female	en_US
dc.subject	Humans	en_US
dc.subject	Male	en_US
dc.subject	Survival Analysis	en_US
dc.subject	Risk Factors	en_US
dc.subject	Prevalence	en_US
dc.subject	Incidence	en_US
dc.subject	Disease Progression	en_US
dc.subject	age	en_US
dc.subject	Age Factors	en_US
dc.subject	Continental Population Groups	en_US
dc.subject	epidemiology	en_US
dc.subject	gender	en_US
dc.subject	incidence	en_US
dc.subject	prevalence	en_US
dc.subject	race /ethnicity	en_US
dc.subject	Sex Factors	en_US
dc.subject	survival /mortality	en_US
dc.subject	Systemic lupus erythematosus	en_US
dc.subject	Age of Onset	en_US
dc.subject	Lupus Erythematosus, Systemic/epidemiology/mortality	en_US
dc.subject	United States/epidemiology	en_US
dc.title	Epidemiology of systemic lupus erythematosus	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1080/1744666X.2017.1327352
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn	1744-8409