Universidad Peruana Cayetano Heredia

Factors affecting lactoferrin concentration in human milk: how much do we know?

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dc.contributor.author Villavicencio, Aasith
dc.contributor.author Rueda, Maria S.
dc.contributor.author Turin, Christie G.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2019-01-25T16:59:38Z
dc.date.available 2019-01-25T16:59:38Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/4908
dc.description.abstract Lactoferrin (LF) is a breast milk glycoprotein with antimicrobial and anti-inflammatory effects. Its beneficial properties in infants, especially in those born preterm, are currently being studied in clinical trials. However, the maternal and nursing infant factors that may affect LF concentration in breast milk are still not clear. We conducted a systematic review to investigate the factors that may affect the concentration of LF in breast milk. We used a 2-step approach to identify the eligible studies according to inclusion/exclusion criteria, and to determine which studies would be considered. We included 70 qualified articles from 29 countries with publication dates ranging from 1976 to 2015. We described the correlation between LF concentration in breast milk and lactation stage; 10 maternal factors, such as race, parity, among others; and 2 infant factors: infections and prematurity. Colostrum has the highest LF levels, but they decrease with days postpartum. No other factor has been consistently associated with LF concentration. A major limitation of the majority of the published studies is the small sample size and the different methods used to measure LF concentration. Therefore, there is a need for large, multicenter studies with standardized study design, sample collection, and LF measurement methods to identify clinically significant factors associated with LF expression in breast milk, which will help promote exclusive breastfeeding in preterm infants. en_US
dc.language.iso eng
dc.publisher NRC Research Press
dc.relation.ispartofseries Biochemistry and Cell Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Lactation en_US
dc.subject Milk, Human/metabolism en_US
dc.subject lactoferrin en_US
dc.subject lactoferrine en_US
dc.subject breast milk en_US
dc.subject facteurs maternels en_US
dc.subject facteurs neonataux en_US
dc.subject lactation en_US
dc.subject lait maternel en_US
dc.subject maternal factors en_US
dc.subject neonatal factors en_US
dc.subject Lactoferrin/metabolism en_US
dc.title Factors affecting lactoferrin concentration in human milk: how much do we know? en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1139/bcb-2016-0060
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1208-6002


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