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Is the immune neuroendocrine system the connection between epipharyngitis and chronic fatigue syndrome induced by HPV vaccine?

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dc.contributor.author Jara, Luis J.
dc.contributor.author Izquierdo, Elva
dc.contributor.author Medina, Gabriela
dc.date.accessioned 2019-01-25T17:00:26Z
dc.date.available 2019-01-25T17:00:26Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/4919
dc.description.abstract An interesting study published in this issue of Immunologic Research, by Hotta et al., analyzed forty-one patients who develop chronic fatigue syndrome (CFS) after HVP vaccine. All patients had at least two major criteria of the autoimmune/inflammatory syndrome induced by adjuvants or ASIA proposed by Shoenfeld et al. in 2011, and all patients had severe chronic epipharyngitis. Sixteen patients were treated with abrasive ZnCl2 procedure on epipharynx mucosa, and the authors observed significant improvement of CFS symptoms in 81.2 %, with a complete cure in four patients (25 %). These findings are relevant, because at this time, CFS is an untreatable disease opening the door for a clinical trial. The authors proposed that the possible explanations of improvement of patients treated with abrasive ZnCl2 could be related to hypothalamic pituitary adrenal (HPA) axis normalization, which probably it was previously altered after HPV vaccine with the consequent development of CFS, suggesting an abnormal immune neuroendocrine interaction... en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1559-0755
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Immune System en_US
dc.subject Papillomavirus Vaccines en_US
dc.subject Fatigue Syndrome, Chronic en_US
dc.subject Neurosecretory Systems en_US
dc.title Is the immune neuroendocrine system the connection between epipharyngitis and chronic fatigue syndrome induced by HPV vaccine? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12026-016-8854-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03

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