Lactoferrin and prematurity: a promising milk protein?

Ochoa Woodell, Theresa Jean; Sizonenko, Stephane V.

dc.contributor.author	Ochoa Woodell, Theresa Jean
dc.contributor.author	Sizonenko, Stephane V.
dc.date.accessioned	2019-01-25T17:00:26Z
dc.date.available	2019-01-25T17:00:26Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4920
dc.description.abstract	Lactoferrin (Lf) is the major whey protein in milk, with multiple beneficial health effects including direct antimicrobial activities, anti-inflammatory effects, and iron homeostasis. Oral Lf supplementation in human preterm infants has been shown to reduce the incidence of sepsis and necrotizing enterocolitis. In preclinical models of antenatal stress and perinatal brain injury, bovine Lf protected the developing brain from neuronal loss, improved connectivity, increased neurotrophic factors, and decreased inflammation. It also supported brain development and cognition. Further, Lf can prevent preterm delivery by reducing proinflammatory factors and inhibiting premature cervix maturation. We review here the latest research on Lf in the field of neonatology.	en_US
dc.language.iso	eng
dc.publisher	NRC Research Press
dc.relation.ispartofseries	Biochemistry and Cell Biology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Humans	en_US
dc.subject	Animals	en_US
dc.subject	Cattle	en_US
dc.subject	brain	en_US
dc.subject	cerveau	en_US
dc.subject	infection	en_US
dc.subject	lactoferrin	en_US
dc.subject	lactoferrine	en_US
dc.subject	prematurite	en_US
dc.subject	prematurity	en_US
dc.subject	Anti-Infective Agents/pharmacology	en_US
dc.subject	Infant, Premature/metabolism	en_US
dc.subject	Lactoferrin/pharmacology	en_US
dc.title	Lactoferrin and prematurity: a promising milk protein?	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1139/bcb-2016-0066
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn	1208-6002