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Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin

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dc.contributor.author Gomes, Claudia
dc.contributor.author Martinez-Puchol, Sandra
dc.contributor.author Palma, Noemi
dc.contributor.author Horna, Gertrudis
dc.contributor.author Ruiz-Roldan, Lidia
dc.contributor.author Pons, Maria J.
dc.contributor.author Ruiz, Joaquim
dc.date.accessioned 2019-01-25T17:00:26Z
dc.date.available 2019-01-25T17:00:26Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/4922
dc.description.abstract From its introduction in 1952 onwards, the clinical use of macrolides has been steadily increasing, both in human and veterinary medicine. Although initially designed to the treatment of Gram-positive microorganisms, this antimicrobial family has also been used to treat specific Gram-negative bacteria. Some of them, as azithromycin, are considered in the armamentarium against Enterobacteriaceae infections. However, the facility that this bacterial genus has to gain or develop mechanisms of antibiotic resistance may compromise the future usefulness of these antibiotics to fight against Enterobacteriaceae infections. The present review is focused on the mechanisms of macrolide resistance, currently described in Enterobacteriaceae. en_US
dc.language.iso eng
dc.publisher Taylor & Francis
dc.relation.ispartof urn:issn:1549-7828
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject 23S rRNA en_US
dc.subject esterases en_US
dc.subject methylases en_US
dc.subject phospotransferases en_US
dc.subject ribosomal mutations en_US
dc.subject Drug Resistance, Bacterial en_US
dc.subject Anti-Bacterial Agents/pharmacology en_US
dc.subject Azithromycin/pharmacology en_US
dc.subject Enterobacteriaceae Infections/drug therapy/microbiology en_US
dc.subject Enterobacteriaceae/drug effects/genetics/metabolism en_US
dc.subject Macrolides/pharmacology en_US
dc.title Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.3109/1040841X.2015.1136261
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01

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