Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin

Gomes, Claudia; Ruiz, Joaquim; Martinez-Puchol, Sandra; Horna, Gertrudis; Palma, Noemi; Ruiz-Roldan, Lidia; Pons, Maria J.

dc.contributor.author	Gomes, Claudia
dc.contributor.author	Martinez-Puchol, Sandra
dc.contributor.author	Palma, Noemi
dc.contributor.author	Horna, Gertrudis
dc.contributor.author	Ruiz-Roldan, Lidia
dc.contributor.author	Pons, Maria J.
dc.contributor.author	Ruiz, Joaquim
dc.date.accessioned	2019-01-25T17:00:26Z
dc.date.available	2019-01-25T17:00:26Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4922
dc.description.abstract	From its introduction in 1952 onwards, the clinical use of macrolides has been steadily increasing, both in human and veterinary medicine. Although initially designed to the treatment of Gram-positive microorganisms, this antimicrobial family has also been used to treat specific Gram-negative bacteria. Some of them, as azithromycin, are considered in the armamentarium against Enterobacteriaceae infections. However, the facility that this bacterial genus has to gain or develop mechanisms of antibiotic resistance may compromise the future usefulness of these antibiotics to fight against Enterobacteriaceae infections. The present review is focused on the mechanisms of macrolide resistance, currently described in Enterobacteriaceae.	en_US
dc.language.iso	eng
dc.publisher	Taylor and Francis
dc.relation.ispartofseries	Critical Reviews in Microbiology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Humans	en_US
dc.subject	Animals	en_US
dc.subject	23S rRNA	en_US
dc.subject	esterases	en_US
dc.subject	methylases	en_US
dc.subject	phospotransferases	en_US
dc.subject	ribosomal mutations	en_US
dc.subject	Drug Resistance, Bacterial	en_US
dc.subject	Anti-Bacterial Agents/pharmacology	en_US
dc.subject	Azithromycin/pharmacology	en_US
dc.subject	Enterobacteriaceae Infections/drug therapy/microbiology	en_US
dc.subject	Enterobacteriaceae/drug effects/genetics/metabolism	en_US
dc.subject	Macrolides/pharmacology	en_US
dc.title	Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.3109/1040841X.2015.1136261
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn	1549-7828