Universidad Peruana Cayetano Heredia

Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: the Altitude IBD Study

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dc.contributor.author Vavricka, Stephan
dc.contributor.author Ruiz, Pedro A.
dc.contributor.author Scharl, Sylvie
dc.contributor.author Biedermann, Luc
dc.contributor.author Scharl, Michael
dc.contributor.author de Valliere, Cheryl
dc.contributor.author Lundby, Carsten
dc.contributor.author Wenger, Roland H.
dc.contributor.author Held, Leonhard
dc.contributor.author Merz, Tobias M.
dc.contributor.author Gassmann, Max
dc.contributor.author Lutz, Thomas
dc.contributor.author Kunz, Andres
dc.contributor.author Bron, Denis
dc.contributor.author Fontana, Adriano
dc.contributor.author Strauss, Laura
dc.contributor.author Weber, Achim
dc.contributor.author Fried, Michael
dc.contributor.author Rogler, Gerhard
dc.contributor.author Zeitz, Jonas
dc.date.accessioned 2019-01-25T17:00:27Z
dc.date.available 2019-01-25T17:00:27Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4943
dc.description.abstract INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic intestinal disorder, often leading to an impaired quality of life in affected patients. The importance of environmental factors in the pathogenesis of IBD, including their disease-modifying potential, is increasingly recognised. Hypoxia seems to be an important driver of inflammation, as has been reported by our group and others. The aim of the study is to evaluate if hypoxia can alter disease activity of IBD measured by Harvey-Bradshaw Activity Index in Crohn's disease (increase to >/=5 points) and the partial Mayo Score for ulcerative colitis (increase to >/=2 points). To test the effects of hypoxia under standardised conditions, we designed a prospective and controlled investigation in healthy controls and patients with IBD in stable remission. METHODS AND ANALYSIS: This is a prospective, controlled and observational study. Participants undergo a 3-hour exposure to hypoxic conditions simulating an altitude of 4000 metres above sea level (m.a.s.l.) in a hypobaric pressure chamber. Clinical parameters, as well as blood and stool samples and biopsies from the sigmoid colon are collected at subsequent time points. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries BMJ Open
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject Young Adult en_US
dc.subject Middle Aged en_US
dc.subject Prospective Studies en_US
dc.subject Biopsy en_US
dc.subject Blood Pressure en_US
dc.subject Research Design en_US
dc.subject Altitude en_US
dc.subject Severity of Illness Index en_US
dc.subject Healthy Volunteers en_US
dc.subject Organ Size en_US
dc.subject Sigmoidoscopy en_US
dc.subject Hypoxia en_US
dc.subject Crohn's disease en_US
dc.subject Ulcerative colitis en_US
dc.subject Angiotensins/blood/urine en_US
dc.subject Colitis, Ulcerative/complications/pathology/physiopathology en_US
dc.subject Colon, Sigmoid/pathology en_US
dc.subject Crohn Disease/complications/pathology/physiopathology en_US
dc.subject Cytokines/metabolism en_US
dc.subject Feces/chemistry en_US
dc.subject Hypoxia-Inducible Factor 1/genetics/metabolism en_US
dc.subject Hypoxia/complications/physiopathology en_US
dc.subject Leukocyte L1 Antigen Complex/analysis en_US
dc.subject Urinary Bladder/anatomy & histology en_US
dc.subject Vasopressins/blood/urine en_US
dc.title Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: the Altitude IBD Study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/bmjopen-2016-013477
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 2044-6055


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