Revised diagnostic criteria for neurocysticercosis

García Lescano, Héctor Hugo; Gilman, Robert Hugh; Nash, T. E.; Rajshekhar, V.; Vasquez, C. M.; White, A. C. Jr; Singh, G.; Del Brutto, O. H.; Wilkins, P. P.; Salgado, P.

dc.contributor.author	Del Brutto, O. H.
dc.contributor.author	Nash, T. E.
dc.contributor.author	White, A. C. Jr
dc.contributor.author	Rajshekhar, V.
dc.contributor.author	Wilkins, P. P.
dc.contributor.author	Singh, G.
dc.contributor.author	Vasquez, C. M.
dc.contributor.author	Salgado, P.
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2019-01-25T17:00:30Z
dc.date.available	2019-01-25T17:00:30Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4949
dc.description.abstract	BACKGROUND: A unified set of criteria for neurocysticercosis (NCC) has helped to standardize its diagnosis in different settings. METHODS: Cysticercosis experts were convened to update current diagnostic criteria for NCC according to two principles: neuroimaging studies are essential for diagnosis, and all other information provides indirect evidence favoring the diagnosis. Recent diagnostic advances were incorporated to this revised set. RESULTS: This revised set is structured in absolute, neuroimaging and clinical/exposure criteria. Absolute criteria include: histological confirmation of parasites, evidence of subretinal cysts, and demonstration of the scolex within a cyst. Neuroimaging criteria are categorized as major (cystic lesions without scolex, enhancing lesions, multilobulated cysts, and calcifications), confirmative (resolution of cysts after cysticidal drug therapy, spontaneous resolution of single enhancing lesions, and migrating ventricular cysts on sequential neuroimaging studies) and minor (hydrocephalus and leptomeningeal enhancement). Clinical/exposure criteria include: detection of anticysticercal antibodies or cysticercal antigens by well-standardized tests, systemic cysticercosis, evidence of a household Taenia carrier, suggestive clinical manifestations, and residency in endemic areas. Besides patients having absolute criteria, definitive diagnosis can be made in those having two major neuroimaging criteria (or one major plus one confirmative criteria) plus exposure. For patients presenting with one major and one minor neuroimaging criteria plus exposure, definitive diagnosis of NCC requires the exclusion of confounding pathologies. Probable diagnosis is reserved for individuals presenting with one neuroimaging criteria plus strong evidence of exposure. CONCLUSIONS: This revised set of diagnostic criteria provides simpler definitions and may facilitate its more uniform and widespread applicability in different scenarios.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Journal of the Neurological Sciences
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Humans	en_US
dc.subject	Neurocysticercosis	en_US
dc.subject	Cysticercosis	en_US
dc.subject	Taenia solium	en_US
dc.subject	Diagnostic criteria, epilepsy, intracranial hypertension	en_US
dc.subject	Neuroimaging	en_US
dc.subject	Brain/diagnostic imaging	en_US
dc.subject	Neurocysticercosis/diagnosis	en_US
dc.title	Revised diagnostic criteria for neurocysticercosis	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1016/j.jns.2016.11.045
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn	1878-5883