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The need for randomised controlled trials of isoniazid monoresistant tuberculosis treatment

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dc.contributor.author Otero Vegas, Larissa
dc.contributor.author Villegas, Leonela
dc.contributor.author Huaman, Moises
dc.contributor.author Sterling, Timothy
dc.contributor.author Seas Ramos, Carlos Rafael
dc.date.accessioned 2019-01-25T17:00:30Z
dc.date.available 2019-01-25T17:00:30Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4959
dc.description.abstract We read with interest the meta-analysis by Medea Gegia and colleagues that reviewed treatment outcomes of isoniazid-resistant tuberculosis when treated with first-line drugs. The authors reviewed all studies published before March, 2015, and focused on the effect of isoniazid monoresistance on microbiological outcomes of tuberculosis treatment. The study found that failure, relapse, and acquired drug resistance were more frequent among patients infected with isoniazid-resistant Mycobacterium tuberculosis. Deaths on tuberculosis treatment were not reported, because the analysis was per-protocol and aimed to report objective microbiological endpoints... en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Lancet. Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Antitubercular Agents en_US
dc.subject Isoniazid en_US
dc.subject Humans en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Rifampin en_US
dc.subject Tuberculosis en_US
dc.title The need for randomised controlled trials of isoniazid monoresistant tuberculosis treatment en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/S1473-3099(17)30121-4
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1474-4457

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