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Type B Insulin Resistance in Peru

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dc.contributor.author Zelada, Henry
dc.contributor.author Gamarra, Dante
dc.contributor.author Arbanil, Hugo
dc.contributor.author Manrique, Helard
dc.date.accessioned 2019-01-25T17:00:30Z
dc.date.available 2019-01-25T17:00:30Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/4964
dc.description.abstract Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a history of RA, SLE and Hashimoto-thyroiditis that presented with cachexia, acanthosis-nigricans, hirsutism, negative anti-insulin-ab and glucose level between 400 to 700 mg/dl, despite a total insulin dose of 1000 IU/day. She received pulses of cyclophosphamide along with prednisone. One year later the patient was off insulin and with HbA1c of 5.6%. The second case is a 42-year-old female patient that presented with polyuria, polydipsia, cachexia, acanthosis-nigricans, negative glutamic-acid-decarboxilase-ab and positive TPO-ab. She received IV infusion of regular insulin at a rate of 500 UI/d. Two years later she was off insulin with HbA1C of 5.6%. As summary, we reported a case of a disease remitted after receiving immunosuppressive therapy and a case of disease remitted spontaneously. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries American Journal of the Medical Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Developing country en_US
dc.subject Immunosuppressive therapy en_US
dc.subject Insulin resistance en_US
dc.subject Insulin Resistance en_US
dc.subject Latin America en_US
dc.subject Peru en_US
dc.subject Adult en_US
dc.subject Autoantibodies/immunology en_US
dc.subject Autoimmune Diseases/drug therapy/immunology en_US
dc.subject Cyclophosphamide/administration & dosage/therapeutic use en_US
dc.subject Drug Therapy, Combination en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Immunosuppressive Agents/administration & dosage/therapeutic use en_US
dc.subject Peru en_US
dc.subject Prednisone/administration & dosage/therapeutic use en_US
dc.subject Receptor, Insulin/immunology en_US
dc.subject Remission Induction en_US
dc.title Type B Insulin Resistance in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.amjms.2016.07.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1538-2990


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