Universidad Peruana Cayetano Heredia

The risk of bias of animal experiments in implant dentistry: a methodological study

Mostrar el registro sencillo del ítem

dc.contributor.author Faggion, C. M.
dc.contributor.author Diaz, K. T.
dc.contributor.author Aranda, L.
dc.contributor.author Gabel, F.
dc.contributor.author Listl, S.
dc.contributor.author Alarcon, M. A.
dc.date.accessioned 2019-01-25T17:02:40Z
dc.date.available 2019-01-25T17:02:40Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4972
dc.description.abstract Objectives: To evaluate the risk of bias (ROB) in reports of randomised controlled trials (RCTs) of animal experiments published in implant dentistry, and to explore the association between animal experiment characteristics and ROB. Material and methods: We searched the MEDLINE (via PubMed), SCOPUS and SciELO databases from 2010 to March 2015 for reports of RCTs of animal experiments published in implant dentistry. We evaluated independently and in duplicate the ROB of these experiments by the use of a tool specifically developed to evaluate ROB in animal studies, the SYRCLE's tool. ROB was judged as low, high or unclear (when there was not enough information to judge ROB). We used univariate and multivariate logistic regression analyses to evaluate the association of specific study characteristics and extent of ROB. Results: We initially selected 850 publications and 161 reports of animal experiments were included. For a total of 1449 entries (records), 486 (34%) were rated as low ROB. High ROB was attributed to 80 (6%) of entries, and 883 (60%) entries were rated as unclear ROB. The characteristics impact factor (IF), reporting of standard error (SE) and reporting of confidence interval (CI) were significantly associated with low ROB in some SYRCLE domains. ConclusionsA substantial number of items with unclear ROB were observed in this sample of animal experiments in implant dentistry. Furthermore, the present findings suggest that implant dentistry animal experiments published in journals with higher IF and better report of measures of precision; that is, CI and SE may have lower ROB than those not having these characteristics. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Clinical Oral Implants Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject treatment en_US
dc.subject animal experimentation en_US
dc.subject quality en_US
dc.subject Dentistry, Oral Surgery & Medicine en_US
dc.subject guidelines en_US
dc.subject Engineering en_US
dc.subject design en_US
dc.subject effect en_US
dc.subject integration en_US
dc.subject methods en_US
dc.subject models en_US
dc.subject risk of bias en_US
dc.subject SYRCLE's tool en_US
dc.title The risk of bias of animal experiments in implant dentistry: a methodological study en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1111/clr.12852
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1600-0501


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas