Obesity as a Conditioning Factor for High-Altitude Diseases

Siques, P.; León-Velarde, Fabiola; San Martin, R.; Brito, J.

dc.contributor.author	San Martin, R.
dc.contributor.author	Brito, J.
dc.contributor.author	Siques, P.
dc.contributor.author	León-Velarde, Fabiola
dc.date.accessioned	2019-01-25T17:02:41Z
dc.date.available	2019-01-25T17:02:41Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4983
dc.description.abstract	Obesity, a worldwide epidemic, has become a major health burden because it is usually accompanied by an increased risk for insulin resistance, diabetes, hypertension, cardiovascular diseases, and even some kinds of cancer. It also results in associated increases in healthcare expenditures and labor and economic consequences. There are also other fields of medicine and biology where obesity or being overweight play a major role, such as high-altitude illnesses (acute mountain sickness, hypoxic pulmonary hypertension, and chronic mountain sickness), where an increasing relationship among these two morbid statuses has been demonstrated. This association could be rooted in the interactions between obesity-related metabolic alterations and critical ventilation impairments due to obesity, which would aggravate hypobaric hypoxia at high altitudes, leading to hypoxemia, which is a trigger for developing high-altitude diseases. This review examines the current literature to support the idea that obesity or overweight could be major conditioning factors at high altitude.	en_US
dc.language.iso	eng
dc.publisher	Karger
dc.relation.ispartofseries	Obesity Facts
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	intermittent hypoxia	en_US
dc.subject	Obesity	en_US
dc.subject	Overweight	en_US
dc.subject	Hypoxia	en_US
dc.subject	risk-factors	en_US
dc.subject	Endocrinology & Metabolism	en_US
dc.subject	nutrition transition	en_US
dc.subject	Nutrition & Dietetics	en_US
dc.subject	illness	en_US
dc.subject	factors	en_US
dc.subject	acute mountain-sickness	en_US
dc.subject	body-mass index	en_US
dc.subject	Conditioning	en_US
dc.subject	energy-balance	en_US
dc.subject	fat distribution	en_US
dc.subject	High-altitude diseases	en_US
dc.subject	qinghai-tibet railroad	en_US
dc.subject	sea-level	en_US
dc.title	Obesity as a Conditioning Factor for High-Altitude Diseases	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1159/000477461
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.18
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.04
dc.relation.issn	1662-4033