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Diarrheagenic Escherichia coli: Prevalence and Pathotype Distribution in Children from Peruvian Rural Communities

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dc.contributor.author Acosta, Gonzalo-J.
dc.contributor.author Vigo, Natalia-I.
dc.contributor.author Durand, David
dc.contributor.author Riveros, Maribel
dc.contributor.author Arango, Sara
dc.contributor.author Zambruni, Mara
dc.contributor.author Ochoa, Theresa-J.
dc.date.accessioned 2019-02-06T14:45:08Z
dc.date.available 2019-02-06T14:45:08Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5015
dc.description.abstract Diarrheagenic Escherichia coli (DEC) are common pathogens of childhood gastrointestinal infections worldwide. To date, research tracking DEC has mainly been completed in urban areas. This study aims to determine the prevalence and pathotype distribution of DEC strains in children from rural Peruvian communities and to establish their association with malnutrition. In this prospective cohort, 93 children aged 6-13 months from rural communities of Urubamba (Andes) and Moyobamba (jungle) were followed for 6 months. Diarrheal and control stool samples were analyzed using multiplex real-time polymerase chain reaction to identify the presence of virulence genes of DEC strains. The overall isolation rate of DEC was 43.0% (352/820). Enteroaggregative E. coli (EAEC, 20.4%), enteropathogenic E. coli (EPEC, 14.2%), and diffusely aggregative E. coli (DAEC, 11.0%) were the most prevalent pathotypes. EAEC was more frequently found in Moyobamba samples (P < 0.01). EPEC was the only strain significantly more frequent in diarrheal than asymptomatic control samples (P < 0.01). DEC strains were more prevalent among younger children (aged 6-12 months, P < 0.05). A decline in height-for-age Z-score (HAZ) was observed in 75.7% of children overall. EAEC was more frequently isolated among children who had a greater HAZ decline (P < 0.05). In conclusion, DEC strains were frequently found in stool samples from children in rural communities of the highlands and jungle of Peru. In addition, children with a greater decline in their growth rate had higher EAEC isolation rates, highlighting the importance of this pathogen in child malnutrition. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:0002-9637
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Enteropathogenic, Escherichia coli en_US
dc.subject Diarrhea/epidemiology/etiology/microbiology en_US
dc.subject Escherichia coli Infections/epidemiology/microbiology en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Infant en_US
dc.subject Male en_US
dc.subject Peru/epidemiology en_US
dc.subject Prevalence en_US
dc.subject Rural Population/statistics & numerical data en_US
dc.title Diarrheagenic Escherichia coli: Prevalence and Pathotype Distribution in Children from Peruvian Rural Communities en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.16-0220
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE

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