Universidad Peruana Cayetano Heredia

A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

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dc.contributor.author Adhikari, Kaustubh
dc.contributor.author Fontanil, Tania
dc.contributor.author Cal, Santiago
dc.contributor.author Mendoza-Revilla, Javier
dc.contributor.author Fuentes-Guajardo, Macarena
dc.contributor.author Chacon-Duque, Juan-Camilo
dc.contributor.author Al-Saadi, Farah
dc.contributor.author Johansson, Jeanette-A.
dc.contributor.author Quinto-Sanchez, Mirsha
dc.contributor.author Acuna-Alonzo, Victor
dc.contributor.author Jaramillo, Claudia
dc.contributor.author Arias, William
dc.contributor.author Barquera-Lozano, Rodrigo
dc.contributor.author Macin-Perez, Gaston
dc.contributor.author Gomez-Valdes, Jorge
dc.contributor.author Villamil-Ramirez, Hugo
dc.contributor.author Hunemeier, Tabita
dc.contributor.author Ramallo, Virginia
dc.contributor.author Silva-de-Cerqueira, Caio-C.
dc.contributor.author Hurtado, Malena
dc.contributor.author Villegas, Valeria
dc.contributor.author Granja, Vanessa
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Poletti, Giovanni
dc.contributor.author Schuler-Faccini, Lavinia
dc.contributor.author Salzano, Francisco-M.
dc.contributor.author Bortolini, Maria-Catira
dc.contributor.author Canizales-Quinteros, Samuel
dc.contributor.author Rothhammer, Francisco
dc.contributor.author Bedoya, Gabriel
dc.contributor.author Gonzalez-Jose, Rolando
dc.contributor.author Headon, Denis
dc.contributor.author Lopez-Otin, Carlos
dc.contributor.author Tobin, Desmond-J.
dc.contributor.author Balding, David
dc.contributor.author Ruiz-Linares, Andres
dc.date.accessioned 2019-02-06T14:45:09Z
dc.date.available 2019-02-06T14:45:09Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5017
dc.description.abstract We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of association reaching genome-wide significance (P values 5 x 10(-8) to 3 x 10(-119)), including 10 novel associations. These include novel loci for scalp hair shape and balding, and the first reported loci for hair greying, monobrow, eyebrow and beard thickness. A newly identified locus influencing hair shape includes a Q30R substitution in the Protease Serine S1 family member 53 (PRSS53). We demonstrate that this enzyme is highly expressed in the hair follicle, especially the inner root sheath, and that the Q30R substitution affects enzyme processing and secretion. The genome regions associated with hair features are enriched for signals of selection, consistent with proposals regarding the evolution of human hair. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Nature Communications
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Continental Population Groups en_US
dc.subject Genome-Wide Association Study en_US
dc.subject Face/physiology en_US
dc.subject Female en_US
dc.subject Gene Expression Regulation/physiology en_US
dc.subject Genetic Variation en_US
dc.subject Hair/growth & development en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Scalp/physiology en_US
dc.title A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/ncomms10815
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.03.00
dc.relation.issn 2041-1723


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