Universidad Peruana Cayetano Heredia

Field evaluation of a dual rapid inmunodiagnostic test for HIV and Syphilis infection in Peru

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dc.contributor.author Bristow, Claire-C.
dc.contributor.author León Sandoval, Segundo Ramos
dc.contributor.author Huang, Emily
dc.contributor.author Ramos, Lourdes-B.
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Flores, Juan-A.
dc.contributor.author Konda, Kelika-A.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, Jeffrey-D.
dc.date.accessioned 2019-02-06T14:45:11Z
dc.date.available 2019-02-06T14:45:11Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5032
dc.description.abstract BACKGROUND: Integrated prevention for HIV and syphilis is warranted because both syphilis and HIV infections have evidence-based, scalable interventions using current health care mechanisms. The advent of dual rapid point-of-care tests, single devices that can detect multiple infections using the same specimen, provides the opportunity to integrate the screening of syphilis into HIV prevention programs, potentially increasing the numbers of people tested and allowing for same-day testing and treatment. The aim of our study was to evaluate the MedMira Multiplo Rapid TP/HIV Antibody Test (MedMira Inc, Halifax, Nova Scotia, Canada), a qualitative, rapid immunoassay that detects antibodies to Treponema pallidum and HIV. METHODS: The reference test for comparison to the T. pallidum component of the Multiplo TP/HIV Test was the T. pallidum particle agglutination assay. For the HIV component, the reference test included a fourth-generation enzyme immunoassay with a confirmatory Western blot test. RESULTS: The sensitivity and specificity for the HIV antibody component were 93.8% (95% confidence interval [CI], 69.8%-99.8%) and 100% (95% CI, 97.7%-100%), respectively. The T. pallidum component of the test had a sensitivity of 81.0% (95% CI, 68.1%-94.6%) and a specificity of 100% (95% CI, 97.6%-100%). CONCLUSIONS: Our study showed excellent performance of the HIV antibody component of the test and very good performance for the T. pallidum antibody component of the MedMira Multiplo Rapid TP/HIV Antibody Test, which should be considered to improve screening coverage. Use of effective dual tests will create improved access to more comprehensive care by integrating the screening of syphilis into HIV prevention programs. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Sexually Transmitted Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Point-of-Care Systems en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Antibodies, Bacterial/immunology en_US
dc.subject Confidence Intervals en_US
dc.subject Female en_US
dc.subject HIV Antibodies/immunology en_US
dc.subject HIV Infections/diagnosis en_US
dc.subject Homosexuality, Male en_US
dc.subject Humans en_US
dc.subject Immunoenzyme Techniques en_US
dc.subject Male en_US
dc.subject Peru/epidemiology en_US
dc.subject Reagent Kits, Diagnostic en_US
dc.subject Sensitivity and Specificity en_US
dc.subject Sex Workers en_US
dc.subject Syphilis/diagnosis en_US
dc.subject Transgender Persons en_US
dc.subject Treponema pallidum/immunology en_US
dc.subject Young Adult en_US
dc.title Field evaluation of a dual rapid inmunodiagnostic test for HIV and Syphilis infection in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1097/OLQ.0000000000000387
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn 1537-4521


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