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Distribution of Glycated Haemoglobin According to Early-Life and Contemporary Characteristics in Adolescents and Adults without Diabetes: The 1982 and 1993 Pelotas Birth Cohorts

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dc.contributor.author Buffarini, Romina
dc.contributor.author Restrepo-Mendez, Maria-Clara
dc.contributor.author Silveira, Vera-M.
dc.contributor.author Miranda, Jaime-J.
dc.contributor.author Goncalves, Helen-D.
dc.contributor.author Oliveira, Isabel-O.
dc.contributor.author Horta, Bernardo-L.
dc.contributor.author Gigante, Denise-P.
dc.contributor.author Menezes, Ana-Maria
dc.contributor.author Assuncao, Maria-Cecilia-F.
dc.date.accessioned 2019-02-06T14:45:11Z
dc.date.available 2019-02-06T14:45:11Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5033
dc.description.abstract AIM: Glycated haemoglobin (HbA1c), a marker of glucose control in individuals with diabetes mellitus, is also related with the incidence of cardiometabolic risk in populations free of disease. The aim of this study was to describe the distribution of HbA1c levels according to early-life and contemporary factors in adolescents and adults without diabetes mellitus. METHODS: HbA1c was measured in adults aged 30 years and adolescents aged 18 years who are participants in the 1982 and 1993 Pelotas Birth Cohorts, respectively. Bivariate and multivariate analyses were performed to describe the HbA1c mean values according to early-life and contemporary characteristics collected prospectively since birth. RESULTS: The distribution of the HbA1c was approximately normal in both cohorts, with a mean (SD) 5.10% (0.43) in the 1982 cohort, and 4.89% (0.50) in the 1993 cohort. HbA1c mean levels were significantly higher in individuals self-reported as black/brown skin color compared to those self-reported as white in both cohorts. Parental history of diabetes was associated with higher HbA1c mean in adults, while stunting at one year old presented an inverse relation with the outcome in adolescents. No other early and contemporary factors were associated with HbA1c levels in adults or adolescents. CONCLUSIONS: We found a consistent relationship between HbA1c and skin color in both cohorts. Further research is needed to understand the role of genomic ancestry on levels of HbA1c concentrations which may inform policies and preventive actions for diabetes mellitus and cardiometabolic risk. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof urn:issn:1932-6203
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Age Factors en_US
dc.subject Brazil en_US
dc.subject Continental Population Groups/statistics & numerical data en_US
dc.subject Female en_US
dc.subject Glycated Hemoglobin A/analysis en_US
dc.subject Health Behavior en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Risk Factors en_US
dc.subject Socioeconomic Factors en_US
dc.title Distribution of Glycated Haemoglobin According to Early-Life and Contemporary Characteristics in Adolescents and Adults without Diabetes: The 1982 and 1993 Pelotas Birth Cohorts en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0162614
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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