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Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series

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dc.contributor.author Cabada, Miguel-M.
dc.contributor.author Lopez, Martha
dc.contributor.author Cruz, Maria
dc.contributor.author Delgado, Jennifer-R.
dc.contributor.author Hill, Virginia
dc.contributor.author White, A. Clinton-Jr
dc.date.accessioned 2019-02-06T14:45:11Z
dc.date.available 2019-02-06T14:45:11Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5035
dc.description.abstract Triclabendazole is reported to be highly effective in treatment of human fascioliasis. We present 7 of 19 selected cases of human fascioliasis referred to our center in the Cusco region of Peru that failed to respond to triclabendazole. These were mostly symptomatic adults of both sexes that continued passing Fasciola eggs in the stool despite multiple treatments with 2 doses of triclabendazole at 10 mg/kg per dose. We documented the presence of eggs by rapid sedimentation and Kato Katz tests after each treatment course. We found that repeated triclabendazole courses were not effective against fascioliasis in this group of people. These findings suggest that resistance to triclabendazole may be an emerging problem in the Andes. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof urn:issn:1935-2735
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Treatment Failure en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Animals en_US
dc.subject Anthelmintics/therapeutic use en_US
dc.subject Benzimidazoles/therapeutic use en_US
dc.subject Fasciola hepatica/drug effects/growth & development en_US
dc.subject Fascioliasis/drug therapy/epidemiology/parasitology en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Peru/epidemiology en_US
dc.subject Triclabendazole en_US
dc.title Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0004361
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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